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ProteomicsRetron Eco2 breaks tRNAs for antiphage defense
Retrons are prokaryotic reverse transcriptase systems that produce multicopy single-stranded DNA (msDNA), yet the principles by which they mediate antiviral defense remain largely unresolved. Here, we dissect the mechanism of Eco2, a minimal retron composed of a single reverse transcriptase–nuclease...
ORGANISM(S): Escherichia coli 
2026-02-23 | PXD067212 | Pride
Retron antiphage defense ribosomal protein s1 
ProteomicsStructural variation of types IV-A1- and IV-A3-mediated CRISPR interference
CRISPR-Cas mediated DNA-interference typically relies on sequence-specific binding and nucleolytic degradation of foreign genetic material. Type IV-A CRISPR-Cas systems diverge from this general mechanism, using a nuclease-independent interference pathway to suppress gene expression for gene regulat...
ORGANISM(S): Pseudomonas oleovorans 
2024-10-08 | PXD056399 | Pride
Cryo-em Type iv crispr-cas 
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