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TranscriptomicsTranscription profiling of human cells to the absence of mitochondrial DNA
Mitochondrial biogenesis is under the control of two different genetic systems: the nuclear genome (nDNA) and the mitochondrial genome (mtDNA). mtDNA is a circular genome of 16.6 kb encoding 13 of the approximately 90 subunits that form the respiratory chain, the remaining ones being encoded by the ...
ORGANISM(S): Homo sapiens 
2009-05-11 | E-GEOD-14900 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of synovial fibroblast ex vivo cultures or whole joints (J), isolated from arthritic mice (197, DARE) and their corresponding normal (F1, wt) littermates
GOAL: Identification of genes and/or pathways involved in the pathogenesis of animal models of Rheumatoid Arthritis (RA). Total RNA samples were extracted from synovial fibroblast ex vivo cultures or whole joints (J), isolated from arthritic mice (197, DARE) and their corresponding normal (F1, wt) l...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-255 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of wild type and myo1 knock out yeast to identify aneuploidies and CNVs in evolved mutants that can successfully perform cytokinesis
In general, yeast strains with myo1 knocked out cannot perform cytokinesis, but some evolve new ways of accomplishing the task. This is an examination of aneuploidies and CNVs in a selection of evolved mutants that can successfully perform cytokinesis. The purpose is to attempt a molecular charact...
ORGANISM(S): Saccharomyces cerevisiae 
2008-11-24 | E-TABM-557 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of yeast strains with different chromosome copy numbers
Aneuploidy, the condition of having an abnormal number of chromosomes, is a hallmark of cancer cells. Recent work performed in yeast and mouse models suggests that aneuploidy interferes with cell proliferation and organism development. However, other recent experiments suggested that aneuploidy migh...
ORGANISM(S): Saccharomyces cerevisiae 
2010-10-01 | E-MTAB-325 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of yeast strains with different chromosome copy numbers
Aneuploidy, the condition of having an abnormal number of chromosomes, is a hallmark of cancer cells. Recent work performed in yeast and mouse models suggests that aneuploidy interferes with cell proliferation and organism development. However, other recent experiments suggested that aneuploidy migh...
ORGANISM(S): Saccharomyces cerevisiae 
2010-10-01 | E-MTAB-318 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and myo1 knock out yeast to examine differential gene expression patterns in evolved mutants that can successfully perform cytokinesis
In general, yeast strains with myo1 knocked out cannot perform cytokinesis, but some evolve new ways of accomplishing the task. This is an examination of differential gene expression patterns in a selection of evolved mutants that can successfully perform cytokinesis. The purpose is to attempt a m...
ORGANISM(S): Saccharomyces cerevisiae 
2008-11-24 | E-TABM-559 | biostudies-arrayexpress
TranscriptomicsThe Transcriptional Stress Response of Candida albicans to Weak Organic Acids
Candida albicans is the most important fungal pathogen of humans, causing severe infections especially in nosocomial and immunocompromised settings. However, it is also the most prevalent fungus of the normal human microbiome, where it shares its habitat with hundreds of trillions of other microbia...
ORGANISM(S): Candida albicans 
2015-01-28 | E-GEOD-49310 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast treated with rapamycin in a 7-part time series
This experiment was a 7-part time series (or, 2x7 factorial design) examining the effect of rapamycin on gene expression in Saccharomyces cerevisiae. Treated and untreated cultures were compared at 0, 20, 40, 60, 120, 240, and 360 minutes. In the paper, expression ratios (mRNA) at each time point ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-02-05 | E-TABM-639 | biostudies-arrayexpress
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