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TranscriptomicsGene expression in the liver following exposition to 1Gy ionizing radiation
Although major differences in the response of tissues were documented in the literature, the molecular mechanisms underlying tissue radiosensitivity are still fragmentary and need to be study more thoroughly. To this end, a genome wide analysis strategy was used to investigate changes in gene expres...
ORGANISM(S): Mus musculus 
2009-08-03 | E-GEOD-5994 | biostudies-arrayexpress
TranscriptomicsBeta 1 blockers improve survival and provide cardioprotection in septic mice
Septic cardiac dysfunction is a key feature of severe sepsis and septic shock, contributing to multiorgan dysfunction syndrome and death. It has been established that persistent beta adrenergic stimulation is detrimental in sepsis, and that specific beta 1 blockade mitigates excessive systemic infla...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-31175 | biostudies-arrayexpress
TranscriptomicsIdentification of molecular key determinants of the Mycobacterium abscessus smooth and rough morphotypes through transcriptome analyses
In this study, we were interested to get deeper insights into the molecular mechanisms that govern the formation and selection of the different colony morphologies in Mycobacterium abscessus strains, including the potential reversibility of the rough (R) phenotype into a smooth (S) phenotype. We use...
ORGANISM(S): Mycobacterium abscessus 
2013-05-15 | E-GEOD-37984 | biostudies-arrayexpress
TranscriptomicsEvolutionary conserved mutations in PhoPR attenuate the virulence of animal-adapted tuberculosis strains for humans
By genome comparison of 30 MTBC strains, we identified three SNPs affecting the phoPR genes of members of the animal and M. africanum lineages that were not seen in the M. tuberculosis sensu-stricto genomes. The genes phoPR encode a two component regulatory system that is known for its strong impact...
ORGANISM(S): Mycobacterium tuberculosis 
2014-07-07 | E-GEOD-54421 | biostudies-arrayexpress
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