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ProteomicsQuantitative proteomics confirms CpKRS is over-expressed in genetically modified strain.
C. parvum was genetically modified to over-express CpKRS. The CpTK locus was replaced wit a cassette containing CpKRS and the dual reporter-selection marker, Nluc-NeoR, driven by the CpEnolase promoter. Quantitative proteomics analysis confirms over-expression of CpKRS and similar significantly incr...
ORGANISM(S): Cryptosporidium parvum Iowa II 
2024-07-05 | PXD050089 | Pride
Tmt Cryptosporidium Lysyl-trna synthetase Cryptosporidiosis 
ProteomicsThermal proteome profiling in Cryptosporidium parvum
Cryptosporidium lacks tools that can identify the targets of emerging compounds that have been developed against this parasite. Thermal proteomic profiling is an unbiased approach that fulfils this unmet need by detecting changes in the thermal stability of target proteins upon the binding of their ...
ORGANISM(S): Cryptosporidium parvum Iowa II 
2023-06-13 | PXD037942 | Pride
Drug target Lysyl-trna synthetase Cryptosporodium parvum Thermal proteome profiling 
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