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TranscriptomicsMouse Myoblast Pax3, Pax7 overexpression and control
This data set contains 3 replicates each for a Pax7 overexpression, Pax3 overexpression and an empty vector Control Measurement of expression levels in Pax3, Pax3 overepxression and empty vector control
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-32266 | biostudies-arrayexpress
TranscriptomicsPAX3-FOXO1 suppresses cellular senescence through RASSF4-mediated restraint of the mammalian Hippo/MST1 pathway
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the PAX3-FOXO1 fusion gene. Despite its discovery over almost 20 years ago, PAX3-FOXO1 remains an enigmatic tumor driver. Previously, we reported that PAX3-FOXO1 supports aRMS initiation by en...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-40543 | biostudies-arrayexpress
TranscriptomicsPax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers [X_laevis_2]
Neural crest development is orchestrated by a complex and still poorly understood gene regulatory network. Premigratory neural crest is induced at the lateral border of the neural plate by the combined action of signaling molecules and transcription factors such as AP2, Gbx2, Pax3 and Zic1. Among th...
ORGANISM(S): Xenopus laevis 
2013-12-28 | E-GEOD-53677 | biostudies-arrayexpress
TranscriptomicsPax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects
Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacia...
ORGANISM(S): Mus musculus 
2015-04-06 | E-MTAB-3238 | biostudies-arrayexpress
GenomicsGenome-wide map of PAX3-FKHR binding sites in rhabdomyosarcoma
We report the genome-wide maps of PAX3-FKHR binding sites. Chromatin immunoprecipitation was performed against PAX3-FKHR positive (Rh4) and PAX3-FKHR negative (RD) rhabdomyosarcoma cells with a monoclonal antibody (pFM2) specific for the fusion region of PAX3-FKHR. We obtained 4 million sequence t...
ORGANISM(S): Homo sapiens 
2010-08-17 | E-GEOD-19063 | biostudies-arrayexpress
GenomicsChIP-Seq of Pax7 and Pax3 in myoblasts
Examination of binding locations of Pax3 and Pax7 in primary myoblasts UCSC track hub available at: http://www.ogic.ca/projects/Soleimani_2012_Pax7_hub/hub.txt For details on viewing the track hub in the UCSC Genome Browser: http://altair.dartmouth.edu/ucsc/goldenPath/help/hgTrackHubHelp.html#View...
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-25064 | biostudies-arrayexpress
TranscriptomicsTranscriptional Dominance of Pax7 in Adult Myogenesis Is Due to High-Affinity Recognition of Homeodomain Motifs
This SuperSeries is composed of the following subset Series: GSE25064: ChIP-Seq of Pax7 and Pax3 in myoblasts GSE32266: Mouse Myoblast Pax3, Pax7 overexpression and control Refer to individual Series
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-25092 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonal rhabdomyosarcoma (EMRS) culture to identify PAX3-FKHR regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcomas
The overall goal and objective is to study the degree to which PAX3-FKHR accounts for differences between ARMS and ERMS by expressing a construct (termed P3FK/ER) consisting of PAX3-FKHR joined to the estrogen receptor ligand binding domain in an ERMS cell culture system. Experiment Overall Design: ...
ORGANISM(S): Homo sapiens 
2009-03-14 | E-GEOD-15103 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of PAX3 in human eRMS and aRMS cell lines identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR
eRMS and aRMS cell lines were treated with small interference RNA (siRNA) specific for PAX3 or - as negative control - scrambled siRNA(Qiagen, Hombrechtikon, Switzerland). After 24hrs, 48hrs and 72hrs total RNA from each sample was used to prepare biotinylated target RNA using the Affymetrix 'Smal...
ORGANISM(S): Homo sapiens 
2007-06-08 | E-MEXP-1124 | biostudies-arrayexpress
TranscriptomicsPax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers [Xenopus_laevis]
Neural crest development is orchestrated by a complex and still poorly understood gene regulatory network. Premigratory neural crest is induced at the lateral border of the neural plate by the combined action of signaling molecules and transcription factors such as AP2, Gbx2, Pax3 and Zic1. Among th...
ORGANISM(S): Xenopus laevis 
2013-12-28 | E-GEOD-53678 | biostudies-arrayexpress
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