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ProteomicsAn extended PAXT connection is required for turnover of nuclear polyadenylated RNA in human cells
Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT) connection. Besides its core dimer, formed by the exosome co-factor MTR4 and the ZFC3H1 protein, the PAXT connection remains poorly defined. By charact...
ORGANISM(S): Homo Sapiens (human) 
2019-10-31 | PXD016070 | JPOST Repository
UnknownPAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs.
Not available
S-EPMC10598014 | biostudies-literature
UnknownThe human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Not available
S-EPMC7049725 | biostudies-literature
GenomicsPAP-gamma associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs
PAP-gamma associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs
PRJNA781729 | ENA
GenomicsThe Human ZC3H3 and RBM26/27 Proteins Are Critical for PAXT-mediated Nuclear RNA Decay
The Human ZC3H3 and RBM26/27 Proteins Are Critical for PAXT-mediated Nuclear RNA Decay
PRJNA543068 | ENA
TranscriptomicsThe Human ZC3H3 and RBM26/27 Proteins Are Critical for PAXT-mediated Nuclear RNA Decay
Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT) connection. Besides its core dimer, formed by the exosome co-factor MTR4 and the ZFC3H1 protein, the PAXT connection remains poorly defined. By charact...
ORGANISM(S): Homo sapiens 
2020-01-09 | GSE131255 | GEO
GenomicsThe PAXT connection is a modifier of rare codon-enriched protein expression
The PAXT connection is a modifier of rare codon-enriched protein expression
PRJNA1224441 | ENA
UnknownStructural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.
Not available
S-EPMC9402713 | biostudies-literature
GenomicsPAP-gamma associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs
Pervasive transcription of the human genome generates an abundance of RNAs that must be processed and degraded. The nuclear RNA exosome is the main RNA degradation machinery in the nucleus. However, nuclear exosome must be recruited to its substrates by targeting complexes, such as NEXT or PAXT. By ...
ORGANISM(S): Homo sapiens 
2023-10-02 | GSE189157 | GEO
UnknownDirect coupling of the human nuclear exosome adaptors NEXT and PAXT with transcription termination and processing machineries.
Not available
S-EPMC12873606 | biostudies-literature
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