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MetabolomicsAlignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

Acute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible metabolic commonalities of patients infected with disparate pathogens that cause fever. Three liquid chromatogra...

2023-07-17 | MTBLS4895 | MetaboLights
TranscriptomicsDeciphering the molecular immune response to COVID-19 using single cell multi-omics
Multi-omics single-cell profiling of surface proteins, gene expression and lymphocyte immune receptors from hospitalised COVID-19 patient peripheral blood immune cells and healthy controls donors. Identification of the coordinated immune cell compositional and state changes in response to SARS-CoV-2...
ORGANISM(S): Homo sapiens 
2021-03-17 | E-MTAB-10026 | biostudies-arrayexpress
GenomicsThe genomic complexity of early T-cell progenitor acute lymphoblastic leukemia

CREST

The accurate identification of structural variations using whole-genome DNA sequencing data generated by next-generation sequencing technology is extremely difficult. To address this challenge, we have developed CREST, an algorithm that uses sequencing reads with partial align...

phs000340.v2.p1 | EGA
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
GenomicsGenome-Wide Analysis of Hypodiploid Acute Lymphoblastic Leukemia

Hypodiploid acute lymphoblastic leukemia (ALL) is an aggressive form of leukemia characterized by multiple whole chromosomal losses and very poor outcome. Here we report an integrative genomic analysis that identifies multiple subtypes of hypodiploid ALL characterized by variation in the degree o...

phs000341.v1.p1 | EGA
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - 10x data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. RNA-seq was done usin...
ORGANISM(S): Homo sapiens 
2018-10-02 | E-MTAB-6701 | biostudies-arrayexpress
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - Smartseq 2 data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. This part contains RN...
ORGANISM(S): Homo sapiens 
2019-08-21 | E-MTAB-6678 | biostudies-arrayexpress
TranscriptomicsThe Genetic Basis of Hypodiploid Acute Lymphoblastic Leukemia
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), characterized by aneuploidy and poor outcome, is unknown. Here, using complementary genome-wide profiling approaches, we show that hypodiploid ALL comprises two major subtypes that differ in the severity of aneuploidy, transcriptio...
ORGANISM(S): Homo sapiens 
2013-01-15 | E-GEOD-27237 | biostudies-arrayexpress
UnknownPain Coping Skills Training for Patients Receiving Hemodialysis: The HOPE Consortium Randomized Clinical Trial.
Not available
S-EPMC11791705 | biostudies-literature
UnknownThe Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.
Not available
S-EPMC9447373 | biostudies-literature
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