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TranscriptomicsLoss of the DNA methyltransferase MET1 induces H3K9 hypermethylation at PcG target genes in Arabidopsis, and relocation of H3K27 trimethylation to transposons [RNA-seq]
Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein coding genes, whil...
ORGANISM(S): Arabidopsis thaliana 
2016-06-22 | E-GEOD-83607 | biostudies-arrayexpress
TranscriptomicsLoss of the DNA methyltransferase MET1 induces H3K9 hypermethylation at PcG target genes in Arabidopsis, and relocation of H3K27 trimethylation to transposons.
Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein coding genes, whil...
ORGANISM(S): Arabidopsis thaliana 
2013-03-02 | E-GEOD-37075 | biostudies-arrayexpress
TranscriptomicsLoss of the DNA methyltransferase MET1 induces H3K9 hypermethylation at PcG target genes in Arabidopsis, and relocation of H3K27 trimethylation to transposons [array]
Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein coding genes, whil...
ORGANISM(S): Arabidopsis thaliana 
2016-06-22 | E-GEOD-83606 | biostudies-arrayexpress
TranscriptomicsL3MBTL2 protein acts in concert with PcG protein mediated monoubiquitination of H2A to establish a repressive chromatin structure [ChIP-chip data].
Human  MBT  domain‐containing  protein  L3MBTL2  was  found  to  be  an  integral  component  of   a  protein  complex  that  we  termed  Polycomb  Repressive  Complex  1‐like  3  (PRC1L3)  given  the  presence   of  the  PcG  proteins  RING1,  RING2  and  PCGF6.  L3MBTL2  binds  chromatin  in  a  h...
ORGANISM(S): Homo sapiens 
2011-06-07 | E-GEOD-28161 | biostudies-arrayexpress
GenomicsL3MBTL2 protein acts in concert with PcG protein mediated monoubiquitination of H2A to establish a repressive chromatin structure [ChIP-Seq data].
Human MBT domain-containing protein L3MBTL2 was found to be an integral component of a protein complex that we termed Polycomb Repressive Complex 1-like 3 (PRC1L3) given the presence of the PcG proteins RING1, RING2 and PCGF6. L3MBTL2 binds chromatin in a histone modification-independent manner and ...
ORGANISM(S): Homo sapiens 
2011-06-07 | E-GEOD-28162 | biostudies-arrayexpress
TranscriptomicsComplex patterns of accessibility discriminate sites of PcG repression, H4K16 acetylation and replication initiation
Full title: Complex patterns of genome accessibility discriminate sites of PcG repression, H4K16 acetylation and replication initiation Histone modifications have been proposed to regulate gene expression in part by modulating DNA accessibility and higher-order chromatin structure. However, there i...
ORGANISM(S): Drosophila melanogaster 
2010-03-16 | E-GEOD-17697 | biostudies-arrayexpress
GenomicsSex comb on midleg (Scm) is a functional link between PcG repressive complexes in Drosophila
We profiled Sex comb on midleg (Scm), Pc and E(z) in fly embryos and S2 based on BioTAP-XL ChIP-seq. ChIP-seq revealed that Scm is co-localized with PRC1, PRC2, and H3K27me3 in both S2 cells and embryos. Genomic binding/occupancy profiling of Scm, Pc and E(z) by high throughput sequencing
ORGANISM(S): Drosophila melanogaster 
2015-07-09 | E-GEOD-66183 | biostudies-arrayexpress
TranscriptomicsChromatin immunopreciptiation to determine the genome wide distribution of PcG and TrxG proteins in Drosophila - part II
We used ChIP on chip assays to determine the genome wide distribution of a large set of PcG and trxG proteins, their associated histone marks and four candidate DNA-binding factors for PcG protein recruitment.
ORGANISM(S): Drosophila melanogaster 
2008-07-26 | E-MTAB-45 | biostudies-arrayexpress
TranscriptomicsGenome-wide Identification of Polycomb Target Genes Reveals a Functional Association of Pho with Scm in Bombyx mori
Polycomb group (PcG) proteins are involved in chromatin modifications for maintaining gene repression that play important roles in the regulation of gene expression, tumorigenesis, chromosome X-inactivation, and genomic imprinting in Drosophila melanogaster, mammals, and even plants. PcG proteins ac...
ORGANISM(S): Bombyx mori 
2012-04-17 | E-GEOD-34246 | biostudies-arrayexpress
TranscriptomicsExpression data from Ler and TOP1a-2 inflorescences
DNA topoisomerases release supercoils in DNA introduced during replication or transcription. How DNA topoisomerases impact transcription in the context of eukaryotic chromatin is poorly understood. In this study, using a floral stem cell model in Arabidopsis, we uncovered a role of TOP1a in Polycomb...
ORGANISM(S): Arabidopsis thaliana 
2014-10-14 | E-GEOD-42403 | biostudies-arrayexpress
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