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TranscriptomicsTranscription profiling of human A549 lung cancer cells treated with actinomycin D and sapphyrin PCI-2050 a new class of tumor-selective inhibitors of gene expression.
The goal of this project was to characterize changes in gene expression in response to the anti-cancer agent sapphyrin PCI-2050. Cultured A549 human lung cancer cells were treated with sapphyrin PCI-2050 or actinomycin D.
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-6400 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 induced tumours in mice treated with PCI-5002, PCI-5003, or control vehicle
We have demonstrated that water-soluble zinc ionophores can be administered to mice at relatively high doses and inhibit the growth of A549 lung cancer cells grown in xenograft models. Gene expression profiles of tumor specimens harvested from mice four hours after treatment confirmed that the acti...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6962 | biostudies-arrayexpress
GenomicsBacillus atrophaeus strain:PCI 246
Bacillus atrophaeus strain:PCI 246 Genome sequencing and assembly
PRJNA243867 | ENA
GenomicsHDAC inhibitor PCI-24781 inhibits metastasis in breast cancer
HDAC inhibitor PCI-24781 inhibits metastasis in breast cancer
PRJNA630975 | ENA
TranscriptomicsTranscription profiling of A549 lung cancer cultures treated with the lead compound PCI-5002 supplemeted with zinc reveals synthesis and anticancer properties of water-soluble zinc ionophores
We have shown that water solubilized versions of a zinc ionophore increase intracellular concentrations of free zinc and have antiproliferative activity in exponential phase A549 lung cancer cultures. The gene expression profiles of A549 lung cancer cultures treated with the lead compound PCI-5002 r...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6960 | biostudies-arrayexpress
TranscriptomicsA GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes.
GNAS, a gene encoding G-protein stimulating alpha subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which is an indolent and slow-growing pancreatic neoplasm that secretes abundant mucin. GNAS mutation is not observed in conventional ductal adenocarcinomas of the pa...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-53350 | biostudies-arrayexpress
TranscriptomicsHDAC inhibitor PCI-24781 inhibits metastasis in breast cancer
RNA-seq analysis was performed to identify key signaling responding to PCI-24781 in MDA-MB-231
ORGANISM(S): Homo sapiens 
2021-05-07 | GSE150038 | GEO
TranscriptomicsPercutaneous Collagen Induction (PCI) in rat
The purpose of the present study is to determine the effect of Percutaneous Collagen Induction (PCI) on the epidermis and dermis, including the systemic inflammatory response on gene expression level using microarray analysis. PCI Therapy is an alternative for safely treating wrinkles and scars and ...
ORGANISM(S): Rattus norvegicus 
2008-05-31 | GSE11617 | GEO
TranscriptomicsCultured A549 lung cancer cells treated with actinomycin D and sapphyrin PCI-2050
The goal of this project was to characterize changes in gene expression in response to the anti-cancer agent sapphyrin PCI-2050. Cultured A549 human lung cancer cells were treated with sapphyrin PCI-2050 or actinomycin D, a known transcripitonal inhibitor. The gene expression profiles of drug-treate...
ORGANISM(S): Homo sapiens 
2006-12-01 | GSE6400 | GEO
TranscriptomicsChromatin immunoprecipitation in yeast for different affinity-tagged strains (two genotypes compared with wild type)
RNA immunoprecipitation from different affinity-tagged strains. Each hyb compared to a common total RNA.
ORGANISM(S): Schizosaccharomyces pombe 
2004-11-09 | E-MEXP-208 | biostudies-arrayexpress
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