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MetabolomicsMetabolomics analysis of AsPC-1 PDAC cells treated with Porcupine inhibitor (LGK974)
Not available
ORGANISM(S): Homo sapiens 
ST001902 | MetabolomicsWorkbench
TranscriptomicsMicroarray expression profile analysis of circular RNAs in human pancreatic ductal adenocarcinoma
To explore the potential involvement of circular RNAs (circRNAs) in pancreatic ductal adenocarcinoma (PDAC) oncogenesis, we conducted circRNA profiling in six pairs of human PDAC and adjacent normal tissue by microarray. Our results showed that clusters of circRNAs were aberrantly expressed in PDAC ...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-69362 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma (PDAC)
Determine methylation pattern in PDAC a genome-wide analysis was performed in a cohort of 167 PDAC and 29 adjacent pancreatic tissues samples using the Infinium 450k methylation arrays (Illumina). 167 pancreatic tumors (PDAC) x 29 adjacent -non tumor samples.
ORGANISM(S): Homo sapiens 
2014-07-08 | E-GEOD-49149 | biostudies-arrayexpress
TranscriptomicsExpression profiling of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all common cancers, but divergent outcomes are apparent between patients. To delineate the intertumor heterogeneity that contributes to this, we aimed to identify clinically distinct gene expression-based subgroups. From a cohort of ...
ORGANISM(S): Homo sapiens 
2020-01-25 | E-MTAB-6830 | biostudies-arrayexpress
TranscriptomicsCombinatorial analysis of miRNA and mRNA expression in pancreatic ductal adenocarcinoma (PDAC)_mRNA
miRNAs are known to be involved in PDAC tumorigenesis, but only a few biologically relevant gene targets have been identified. Here we show that three miRNAs (miR-21, miR-23a and miR-27a) act in concert for the cooperative suppression of several tumor suppressor genes of which we experimentally vali...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-41368 | biostudies-arrayexpress
TranscriptomicsCombinatorial analysis of miRNA and mRNA expression in pancreatic ductal adenocarcinoma (PDAC)_miRNA
miRNAs are known to be involved in PDAC tumorigenesis, but only a few biologically relevant gene targets have been identified. Here we show that three miRNAs (miR-21, miR-23a and miR-27a) act in concert for the cooperative suppression of several tumor suppressor genes of which we experimentally vali...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-41369 | biostudies-arrayexpress
TranscriptomicsArray CGH analysis for 29 pancreatic ductal adenocarcinoma (PDAC) samples
Background/Aims: Microarray-based comparative genomic hybridisation (CGH) has allowed high-resolution analysis of DNA copy number alterations across the entire cancer genome. Recent advances in bioinformatics tools enable us to perform a robust and highly sensitive analysis of array CGH data and fac...
ORGANISM(S): Homo sapiens 
2008-12-16 | E-GEOD-9672 | biostudies-arrayexpress
MetabolomicsNon-targeted metabolomics screen comparing metabolite profiles of serum from PDAC-bearing mice that received metronidazole using high-resolution, high-performance LC-MS/MS analysis.
Not available
ORGANISM(S): Mus musculus 
ST002216 | MetabolomicsWorkbench
GenomicsGenome-wide map of GATA6 DNA binding in human PDAC cells
By studying a mouse model, as well as human tumors samples and cell lines, we have revealed a tumor suppressive role for Gata6 in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In order to understand the mechanism underlying such tumor suppressive function, we analyzed the genome-wide ...
ORGANISM(S): Homo sapiens 
2015-02-03 | E-GEOD-47535 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of PDAC tumors
Analysis of myofibroblast ablation at the gene expression level of PDAC tumors. Total RNA optained from pancreas of PDAC mice with and without aSMA myofibroblast ablated In addition, late stage aSMA ablated mice were treated with anti-CTLA4 treatment
ORGANISM(S): Mus musculus 
2015-01-20 | E-GEOD-52812 | biostudies-arrayexpress
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