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MetabolomicsCharacterizing ex vivo models for studying lipid metabolism in triple negative breast cancer

Lipid metabolism drives cancer progression but is difficult to model using conventional methods. In vivo models provide circulating lipids, but are costly and low throughput, while in vitro models lack sufficient lipid availability in culture media. Here, we evaluate the chick chorioallantoic mem...

2026-07-16 | MTBLS13377 | MetaboLights
TranscriptomicsRNAseq analysis of SCLC PDX models
We investigated the gene expression changes in a library of small cell lung carcinoma (SCLC) patient-derived xenograft (PDX) models.
ORGANISM(S): Homo sapiens 
2022-02-07 | E-MTAB-11230 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling of 79 patient derived xenograft (PDX) models
RNA-Seq and a species-specific mapping strategy were used to profile the human and mouse transcriptomes of tumour samples taken from 79 PDX models representing multiple cancer types (19 x breast, 37 x lung, 8 x colorectal, 7 x ovarian, 3 x endometrial, 2 x pancreatic, 2 x ampullary, 1 x leukaemia).
ORGANISM(S): Mus musculus 
2016-03-01 | E-MTAB-3980 | biostudies-arrayexpress
GenomicsRNAseq analysis of meso PDX models
RNAseq analysis of meso PDX models
PRJEB53372 | ENA
GenomicsRNAseq analysis of SCLC PDX models
RNAseq analysis of SCLC PDX models
PRJEB50684 | ENA
TranscriptomicsInvestigation of the transcriptional effects of Bevacizumab treatment in two epithelial ovarian cancer PDX models
PDXs were established from cancer cells contained in ascitic effusions from patients with high-grade serous ovarian cancer, never treated with Bevacizumab. Tumors were propagated in female NOD/SCID mice by intraperitoneal injection of tumor cells. Two PDX models, one B20-4.1.1-Resistant (PDOVCA 69, ...
ORGANISM(S): Homo sapiens 
2024-12-05 | E-MTAB-14679 | biostudies-arrayexpress
ProteomicsQuantification strategy for PDX MS data
Data interpreting of PDX proteome is still a problem because with the growth of human cancerous tissue in an immunodeficient mouse, the endothelial cells and fibroblasts from the host mouse replaced human stromal components, making PDX sample a mixture of human and mouse cells. In this study, we cre...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-05-19 | PXD008611 | Pride
Standard mixture Pdx Lfq Lc-ms/ms 
TranscriptomicsRNAseq analysis of meso PDX models
We investigated the gene expression changes in a library of meso PDX models.
ORGANISM(S): Homo sapiens 
2022-06-17 | E-MTAB-11783 | biostudies-arrayexpress
ProteomicsPeritoneal metastasis of colorectal cancer (pmCRC): Identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models
14 PDX models of pmCRC were established, including 9 matched PD3D/PDX models, and treatment response to 17 SoC and targeted therapies was monitored, which resulted in drug-dependent inter- and intra-patient specific growth inhibition. Analysis of the molecular data of the models and patient tissue r...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-17 | PXD027419 | Pride
Pmcrc Proteomics Biomarkers Pdx Pd3d 
GenomicsRNA-Seq Analysis of Paclitaxel-Resistant PDX Models in Mice
RNA-Seq Analysis of Paclitaxel-Resistant PDX Models in Mice
PRJNA1139078 | ENA
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