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We developed a computational framework that integrates chromosomal copy number and gene expression data for detecting aberrations that promote cancer progression. We demonstrate the utility of this framework using a melanoma dataset. Our analysis correctly identified known drivers of melanoma and pr...
ORGANISM(S): Homo sapiens 
In order to reveal the downstream targets of MAPK in melanoma, we measured the expression of 12 melanoma cell lines pre and post MEK inhibition Samples were treated with 50nM of the MEK inhibitor PD901 and collected 8 hours after treatment
ORGANISM(S): Homo sapiens 
In this study we probe how prototrophic yeast from different environmental backgrounds respond to perturbing agents presented in the context of a conflicting signal, repletion of glucose after transient deprivation. To assess the contribution of genetic v
ORGANISM(S): Saccharomyces cerevisiae 
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