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TranscriptomicsTranscription profiling of tomato - wax biosynthesis of PS mutant fruits
Mature green fruits of the tomato (Solanum lycopersicum L.) cultivar John Baer and Pearson were investigated (fruit developmental category II). John Baer wild type, John Baer LA0063 and Pearson wild type, Pearson 2-303 fruits were used. Tomato mutant plants LA0063 and 2-303 were positional sterile (...
ORGANISM(S): Lycopersicon esculentum 
2009-06-09 | E-MEXP-2164 | biostudies-arrayexpress
MetabolomicsCombined analysis of cecal microbiota and metabolomics reveals the intervention mechanism of Dayuan Yin in acute lung injury

The ancient Chinese medicinal formula, Dayuan Yin (DYY), has a long history of use in treating respiratory ailments and shown to be effective in treating acute infectious diseases. This study aims to explore how DYY may impact intestinal flora and metabolites induced by acute lung injury (ALI). A...

2024-09-20 | MTBLS10741 | MetaboLights
ProteomicsPhosphoproteomics analysis of normal and mutated granulocyte colony stimulating factor receptors
Granulocyte colony stimulating factor receptor (G-CSFR) plays important role in the production of neutrophils from hematopoietic stem cells. Mutated form of the receptor has been directly associated with two distinct malignant phenotype in patients, e.g. acute myeloid leukemia (AML) and chronic neut...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-14 | PXD009311 | Pride
Phosphoproteomics Silac G-csfr signaling 
TranscriptomicsIdentification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk using retrospective epidemiological studies. Here, we sought to prospectively identify chemicals that share transcriptomic signatures with neurological disorders by exposing mouse cortical neuron-enri...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-70249 | biostudies-arrayexpress
TranscriptomicsFunctional redundancy of iron acquisition systems is required for Proteus mirabilis pathogenesis during UTI
Proteus mirabilis is a primary cause of complicated urinary tract infections (UTI). Surprisingly, iron acquisition systems have been poorly characterized in this uropathogen despite the urinary tract being iron-limited. In this report the transcriptome of strain HI4320, cultured under iron limitat...
ORGANISM(S): Proteus mirabilis HI4320 
2010-09-09 | E-GEOD-18051 | biostudies-arrayexpress
TranscriptomicsStudy of poplar shoot apex transcriptomic response to variations in soil water avaialbility
In a context of climate changes, water availability is expected to become a limiting factor for plant growth and to have an impact on forest health. In order to identify genes involved in shoot phenotypic plasticity in response to variations in water availability in trees, gene expression patterns w...
ORGANISM(S): Populus x canadensis 
2014-01-01 | E-GEOD-46605 | biostudies-arrayexpress
TranscriptomicsTime Course of Gene Expression in the Substantia Nigra in Response to Intrastriatal 6-hydroxydopamine in the rat.
The 6-hydroxydopamine (6OHDA) rat model of parkinsonism is among the first, and most commonly used, animal models of Parkinson’s disease. It provides insight into the compensatory changes that occur in the brain after dopamine (DA) neuron degeneration. In order to better define the consequences of s...
ORGANISM(S): Rattus norvegicus 
2014-06-21 | E-GEOD-58710 | biostudies-arrayexpress
TranscriptomicsModulation of gene expression induced by cylindrospermopsin in human intestinal Caco-2 cells
Cylindrospermopsin (CYN) is a cyanotoxin that has been recognised as an emerging potential public health risk. Although CYN toxicity has been demonstrated, the mechanisms involved have not been fully characterised. To identify some key pathways related to this toxicity, we studied the transcriptomic...
ORGANISM(S): Homo sapiens 
2014-03-11 | E-GEOD-55723 | biostudies-arrayexpress
MetabolomicsImmunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains uncl...
2023-05-02 | MTBLS5288 | MetaboLights
TranscriptomicsAIRE hypoexpression and transcriptome profiles correlate with thymic impairment in Down syndrome
Down syndrome (DS) patients frequently develop organ-specific autoimmune disorders, particularly endocrinopathies and coeliac disease, as well as an increased susceptibility to mucosal candidiasis. These clinical features resemble APECED (autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystroph...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-23910 | biostudies-arrayexpress
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