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MetabolomicsBiodiversity in marine invertebrate responses to acute warming revealed by a comparative multi-omics approach
Understanding species' responses to environmental change underpins our abilities to make predictions on future biodiversity under any range of scenarios. In spite of the huge biodiversity in most ecosystems, a model species approach is often taken in environmental studies. To date, we still do not k...
2016-06-23 | MTBLS336 | MetaboLights
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
TranscriptomicsLaternula elliptica gill hypoxia treatment
Two groups of Laternula elliptica, old and young, were subjected to both ambient control and hypoxic conditions, and their gills were extracted and hybridized on an array.
ORGANISM(S): Laternula elliptica 
2013-04-01 | E-MEXP-3611 | biostudies-arrayexpress
ProteomicsGlobal proteomics proteasome mutants
Temperature sensitive(TS)missense mutants have been foundational in the characterization of the function of essential genes due to their pronounced cellular phenotypes that are likely associated with protein functional disruption. However, an unbiased approach for the analysis of the biochemical and...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-11-03 | PXD017223 | Pride
Yeast Tmt Proteasome Tpp 
ProteomicsmTPP of temperature sensitive proteasome mutants
Temperature sensitive (TS) missense mutants have been foundational in the characterization essential gene function. However, an unbiased approach for the analysis of the biochemical and biophysical changes in TS missense mutants within the context of their functional proteomes is lacking. We applied...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-11-03 | PXD017222 | Pride
Tpp Yeast Proteasome Lc-ms/ms 
ProteomicsAffinity Purification Trigger with mTPP
We have applied a BASIL-like approach to increase the signal of low abundance peptides to the study of protein complexes. To accomplish this, we incorporated an affinity purified cleavage and polyadenylation factor (CPF) complex as a “trigger” into our mTPP workflow at a trigger sample to lowest hea...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-09 | PXD020689 | Pride
Ap-ms Tpp Lc-ms/ms 
TranscriptomicsLaternula elliptica siphon hypoxia treatment
The siphon taken from old and young Laternula elliptica, both control and subjected to hypoxic conditions, were compared.
ORGANISM(S): Laternula elliptica 
2014-02-20 | E-MEXP-3613 | biostudies-arrayexpress
ProteomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice.
Combustible cigarette smoking has major impact on human health. In order to reduce smoking-related health risk, the tobacco industry is developing modified risk tobacco products (MRTP). To assess the potential of such a prototype (pMRTP) to reduce health risk, we used C57BL/6 mice, model of chronic ...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-04 | PXD001369 | Pride
Systems toxicology  tobacco-heating  itraq  mouse 
UnknownPIC-SURE: an open-source platform for integrating clinical and genomic data.
Not available
S-EPMC12855934 | biostudies-literature
UnknownKey Findings and Implications of a Recent Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children.
Not available
S-EPMC6212940 | biostudies-literature
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