Sort   by:  
 Page size 
GenomicsMulti-pronged analysis of Pediatric Low-Grade Glioma
Multi-pronged analysis of Pediatric Low-Grade Glioma
PRJNA971603 | ENA
ProteomicsMulti-omics Dissection of MAPK-driven Senescence Unveils Therapeutic Vulnerabilities in KIAA1549::BRAF-fusion Pediatric Low-Grade Glioma Models
This study investigates molecular mechanisms regulating oncogene-induced senescence (OIS) and senescence-associated secretory phenotype (SASP) in pediatric low-grade gliomas (pLGGs). Using multi-omics analysis of a pilocytic astrocytoma cell line, we identified key OIS effectors and pathways affecte...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD060126 | Pride
Senescence-associated secretory phenotype Mapk pathway Multi-omics Oncogene-induced senescence Mapk inhibitor Pediatric low-grade glioma 
UnknownIn silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas.
Not available
S-EPMC12476408 | biostudies-literature
GenomicsIntegrated clinical and molecular landscape of disseminated pediatric low-grade glioma
Integrated clinical and molecular landscape of disseminated pediatric low-grade glioma
PRJNA1206207 | ENA
TranscriptomicsArray-CGH screening of pediatric low-grade astrocytomas (n=66)
DNA copy-number profiling of 66 astrocytomas of WHO °I or °II Comparison of tumor DNA (tumor) versus control DNA (pool of lymphocyte DNA from 10 healthy donors). Whole-genome screening for DNA copy-number aberrations using array-based comparative genomic hybridization (aCGH). Tumor DNA labeled in Cy...
ORGANISM(S): Homo sapiens 
2007-08-10 | E-GEOD-8737 | biostudies-arrayexpress
TranscriptomicsNovel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
The outcome for children with high-grade gliomas (HGG) remains dismal, with a two-year survival rate of only 10-30%. Approximately half of pediatric HGGs are diffuse intrinsic pontine glioma (DIPG), a brainstem tumor that arises almost exclusively in children. Genome-wide analyses of copy number i...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-46190 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analyses of Diffuse Intrinsic Pontine Gliomas
Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to identify therapeutic targets, however lack of patient material for research has limited progress. We evaluated a large cohort of diffuse intrinsic pontine gliomas ...
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-26576 | biostudies-arrayexpress
GenomicsPediatric Low-Grade Glioma RNA and Targeted Sequencing
Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS/MAPK pathway yet show unexplained variability in their clinical outcome. To address this, we characterized a cohort of >1,000 clinically annotated pLGG. 84% of cases harbored a driver alteration, while those w...
EGAS00001004242 | EGA
GenomicGenomic Characterization of Pediatric Low-Grade Gliomas

Pediatric low-grade gliomas (PLGGs) are the most common pediatric brain-tumor, with more than ten histologic subtypes recognized by the World Health Organization. We performed a genomic analysis of 230 PLGGs of which 73 had whole genome/RNA sequencing performed and show that MYB-QKI fusions defin...

phs001054 | dbGaP
TranscriptomicsMulti-pronged analysis of Pediatric Low-Grade Glioma
Multiomic profiling of low-grade glioma
ORGANISM(S): Homo sapiens 
2025-05-30 | GSE232316 | GEO
Sort   by:  
 Page size