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TranscriptomicsGenome-wide analysis of vitamin D receptor (VDR) target genes in THP-1 monocytic leucemia cells
Identification of primary target genes of vitamin D receptor (VDR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with VDR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by VDR. THP-1 cells were treated 4 h either with 0.1% ethanol (v...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-27270 | biostudies-arrayexpress
GenomicsGenome-wide landscape of liver X receptor chromatin binding and gene regulation
Gene expression: Identification of primary target genes of liver X receptor (LXR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with LXR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by LXR. ChIP-Seq: We performed ChIP-seq in macro...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-28319 | biostudies-arrayexpress
TranscriptomicsThe effects of UVB and the organic osmolyte betaine on rat epidermal keratinocytes in an organotypic culture system
Betaine (trimethylglycine) is a non-toxic, highly water-soluble organic osmolyte widely used in skin care due to its assumed moisturizing and protective properties, but only few studies have addressed its specific effects in skin. Here, the cellular and molecular targets of betaine were analyzed by ...
ORGANISM(S): Rattus norvegicus 
2015-10-26 | E-GEOD-63004 | biostudies-arrayexpress
GenomicsShort-term time course of the effects of 1α,25-dihydroxyvitamin D3 treatment on open chromatin regions in THP-1 monocytic leukemia cells
Open chromatin regions have been shown to associate with the location of transcriptiotal enhancers, i.e., the binding locations of DNA-binding transcription factors. To investigate the effects of short-term treatment by the nuclear hormone 1α,25-dihydroxyvitamin D3 (VD), a specific ligand of the tr...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40075 | biostudies-arrayexpress
GenomicsGenome-wide map of vitamin D receptor (VDR) binding in THP-1 cells
Analysis of acute effects of ligand-treatment on vitamin D receptor binding genome-wide using ChIP-seq. THP-1 monocytic leucemia cells were treated with 1?,25(OH)2D3 (1,25D) or left unstimulated to investigate the acute effects of VDR chromatin occupancy. We identified in total 2340 VDR binding site...
ORGANISM(S): Homo sapiens 
2011-08-17 | E-GEOD-27437 | biostudies-arrayexpress
TranscriptomicsExpression Data from Ectopic expression of SUMO-1 in C. elegans
Transgenic C. elegans strains that express human SUMO-1 under the control of pan-neuronal (aex-3) or pan muscular (myo-4) promoters were assayed for gene expression changes. Control N2 non transgenic worms were compared to aex-3::His-SUMO-1 and myo-4::His-SUMO-1 worms in 3 biological replicate popul...
ORGANISM(S): Caenorhabditis elegans 
2011-01-31 | E-GEOD-19972 | biostudies-arrayexpress
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