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MetabolomicsA comprehensive multiomic analysis reveals metabolic reprogramming underlying human Fontan-associated liver disease

BACKGROUND: Single ventricle congenital heart disease (SVCHD) is a severe form of cardiac malformation in which there is only one functional ventricle. The Fontan operation is the current standard of care for SVCHD. Almost all patients who have undergone the Fontan operation develop liver fibrosi...

2024-12-13 | MTBLS10782 | MetaboLights
GenomicsERRγ links adaptive neuronal metabolism to spatial learning and memory [ChIP-Seq]
Neurons utilize glucose to generate adenosine triphosphate (ATP) essential for their survival, excitability and synaptic signaling, as well as initiating changes in neuronal structure and function. Defects in oxidative metabolism and mitochondria functions are also associated with aging and diverse ...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-47134 | biostudies-arrayexpress
TranscriptomicsERRγ links adaptive neuronal metabolism to spatial learning and memory [Array data]
Neurons utilize glucose to generate adenosine triphosphate (ATP) essential for their survival, excitability and synaptic signaling, as well as initiating changes in neuronal structure and function. Defects in oxidative metabolism and mitochondria functions are also associated with aging and diverse ...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-47133 | biostudies-arrayexpress
TranscriptomicsSMRT-RID mutation linked to Type I Pneumocyte Associated Respiratory Distress Syndrome via TR repression
We show that knock-in mutations of the nuclear corepressor SMRT in C57Bl6 mice (SMRTmRID) produces a novel respiratory distress syndrome (RDS) due to prematurity of the type I pneumocyte. Treatment with the anti-thyroid hormone drug, propylthiouracil (PTU), completely rescues the SMRT-induced RDS, ...
ORGANISM(S): Mus musculus 
2011-10-13 | E-GEOD-30661 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3T3-MEFs derived from wild-type and SMRT RID mutants
SMRT (silencing mediator of retinoid and thyroid hormone receptors) is recruited by numerous transcription factors to mediate lineage and signal dependent transcriptional repression. We generated a knock-in mutation in the receptor interaction domain (RID) of SMRT (SMRTmRID) that solely disrupts it...
ORGANISM(S): Mus musculus 
2009-01-18 | E-GEOD-13143 | biostudies-arrayexpress
ProteomicsA.thaliana - Silique, SC (Zhangetal,scidata2019)
abundance based on Spectral counting, Interaction consistency score: 1.9, Coverage: 35
ORGANISM(S): 3702 
2019-00-00 | 2872091233 | PAXDB
ProteomicsA.thaliana - Root, SC (Zhangetal,scidata2019)
abundance based on Spectral counting, Interaction consistency score: 2.2, Coverage: 35
ORGANISM(S): 3702 
2019-00-00 | 1074583746 | PAXDB
ProteomicsA.thaliana - Rosette, SC (Zhangetal,scidata2019)
abundance based on Spectral counting, Interaction consistency score: 1.0, Coverage: 31
ORGANISM(S): 3702 
2019-00-00 | 4176037756 | PAXDB
ProteomicsA.thaliana - Stem, SC (Zhangetal,scidata2019)
abundance based on Spectral counting, Interaction consistency score: 0.8, Coverage: 31
ORGANISM(S): 3702 
2019-00-00 | 2686750703 | PAXDB
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