Sort   by:  
 Page size 
TranscriptomicsExpression data from human Jurkat T cells exposed to 31 compounds
Compounds with direct immunotoxic properties, including metals, mycotoxins, agricultural pesticides and industrial chemicals, form potential human health risks due to exposure through food, drinking water, and the environment. Insights into the mechanisms of action are currently lacking for the majo...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-46909 | biostudies-arrayexpress
UnknownThe impact of PPARα activation on whole genome gene expression in human precision cut liver slices.
Not available
S-EPMC4599789 | biostudies-literature
TranscriptomicsModel steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices [Necrotic compounds exposures]
Although drug induced steatosis represents a mild type of hepatotoxicity, it can progress into more severe non-alcoholic steatohepatitis. Current models used for safety assessment in drug development and chemical risk assessment do not accurately predict steatosis in humans. Therefore, new models ne...
ORGANISM(S): Mus musculus 
2013-12-23 | E-GEOD-51542 | biostudies-arrayexpress
TranscriptomicsModel steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices [Cholestatic compounds exposures]
Although drug induced steatosis represents a mild type of hepatotoxicity, it can progress into more severe non-alcoholic steatohepatitis. Current models used for safety assessment in drug development and chemical risk assessment do not accurately predict steatosis in humans. Therefore, new models ne...
ORGANISM(S): Mus musculus 
2013-12-23 | E-GEOD-51544 | biostudies-arrayexpress
TranscriptomicsModel steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices [Steatogenic compounds exposures]
Although drug induced steatosis represents a mild type of hepatotoxicity, it can progress into more severe non-alcoholic steatohepatitis. Current models used for safety assessment in drug development and chemical risk assessment do not accurately predict steatosis in humans. Therefore, new models ne...
ORGANISM(S): Mus musculus 
2013-12-23 | E-GEOD-51543 | biostudies-arrayexpress
TranscriptomicsThe impact of PPARα activation on whole genome gene expression in human precision-cut liver slices
Background: Studies in mice have shown that PPARα is an important regulator of lipid metabolism in liver and a key transcription factor involved in the adaptive response to fasting. However, much less is known about the role of PPARα in human liver. Here we set out to study the function of PPARα ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-71731 | biostudies-arrayexpress
UnknownProviding Biological Plausibility for Exposure-Health Relationships for the Mycotoxins Deoxynivalenol (DON) and Fumonisin B1 (FB1) in Humans Using the AOP Framework.
Not available
S-EPMC9030459 | biostudies-literature
TranscriptomicsDifferent responses of Caco-2 and MCF-7 cells to silver nanoparticles are based on highly similar mechanisms of action
The mode of action of silver nanoparticles (AgNPs) is suggested to be exerted through both Ag+ and AgNP dependent mechanisms. Ingestion is one of the major NP exposure routes, and potential effects are often studied using Caco-2 cells, a well-established model for the gut epithelium. MCF-7 cells are...
ORGANISM(S): Homo sapiens 
2016-07-30 | E-GEOD-84982 | biostudies-arrayexpress
TranscriptomicsLow dose human APAP exposure
Acetaminophen is the primary cause of acute liver toxicity in Europe/USA. Therefore, the FDA reconsiders recommendations concerning safe acetaminophen dosage/use. Current tests for liver toxicity are no ideal predictive markers for liver injury. Here, ‘omics techniques (global analysis of metabolomi...
ORGANISM(S): Homo sapiens 
2011-07-07 | E-GEOD-30418 | biostudies-arrayexpress
Sort   by:  
 Page size