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UnknownThree-dimensional cage-like microscaffolds for cell invasion studies.
Not available
S-EPMC4650598 | biostudies-literature
TranscriptomicsCopy number profiling via ArrayCGH on high grade serous epithelial ovarian cancer samples from multiple biopsies
We performed Array CGH on 25 patients with high grade serous epithelial ovarian cancer (HGS-EOC): each of this had multiple biopsies taken at the moment of the surgery in different anatomical sites, and 18 had also temporal biopsies taken after several cycles of chemotherapy. Blood was used as contr...
ORGANISM(S): Homo sapiens 
2019-12-19 | E-MTAB-6900 | biostudies-arrayexpress
UnknownGeneration of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties.
Not available
S-EPMC10251795 | biostudies-literature
TranscriptomicsTranscription profiling of human anaplastic large cell lymphoma cell lines - kinase signature
Anaplastic Large Cell Lymphomas (ALCL) represent a subset of lymphomas in which the Anaplastic Lymphoma Kinase (ALK) gene is frequently fused to the NPM gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular transformation in ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6184 | biostudies-arrayexpress
TranscriptomicsAssessment of MEK-ERK pathway targeting by BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias [Patient samples]
Multiple myeloma (MM) is a malignant disorder characterized by the clonal proliferation of plasma cells (PCs) in the bone marrow (BM). The genetic background and clinical course of the disease are largely heterogeneous, and MM pathophysiology ranges from the premalignant condition of monoclonal gamm...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-66291 | biostudies-arrayexpress
TranscriptomicsAssessment of MEK-ERK pathway targeting by BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias [U266 human myeloma cell line]
Multiple myeloma (MM) is a malignant disorder characterized by the clonal proliferation of plasma cells (PCs) in the bone marrow (BM). The genetic background and clinical course of the disease are largely heterogeneous, and MM pathophysiology ranges from the premalignant condition of monoclonal gamm...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-66292 | biostudies-arrayexpress
UnknownAssessing Determinants of Response to PARP Inhibition in Germline <i>ATM</i> Mutant Melanoma.
Not available
S-EPMC12346925 | biostudies-literature
UnknownComorbidities, Cardiovascular Therapies, and COVID-19 Mortality: A Nationwide, Italian Observational Study (ItaliCO).
Not available
S-EPMC7583635 | biostudies-literature
TranscriptomicsTargeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication
RNA-seq of human cells Edited using CRISPR vs parental and Unedited control. We identified a rare homozygous intronic variant in the ATP2B1 locus (rs111337717; chr12:89643729, T>C) that is associated with the severity of COVID-19 (i.e., symptomatic versus asymptomatic patients). Next, we employed ...
ORGANISM(S): Homo sapiens 
2024-05-13 | E-MTAB-13916 | biostudies-arrayexpress
TranscriptomicsTranscriptional characterization of a prospective series of primary plasma cell leukemia revealed genes associated with tumor progression and poorest outcome
Plasma cell leukemia (PCL) is a rare form of plasma cell dyscrasia that presents either as a progression of previously diagnosed multiple myeloma (MM), namely secondary PCL (sPCL), or as the initial manifestation of disease, namely primary PCL (pPCL). Although presenting signs and symptoms include t...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-39925 | biostudies-arrayexpress
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