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TranscriptomicsMicroarray gene expression analysis of T-cell prolymphocytic leukemia (T-PLL) patient samples
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. To characterize the gene expression profiles, 12 T-PLL MNC samples (>90% tumor cell content) were scr...
ORGANISM(S): Homo sapiens 
2017-09-08 | E-MTAB-5916 | biostudies-arrayexpress
GenomicsExome and RNA sequencing of relapsed TCF3-PBX1 t(1;19) acute lymphoblastic leukemia
TCF3-PBX1 (E2A-PBX1) is a recurrent gene fusion in B-cell precursor lymphoblastic leukemia (BCP-ALL), which is caused by the translocation t(1;19)(q23;p13). TCF3-PBX1 BCP-ALL patients typically benefit from chemotherapy; however, many relapse and subsequently develop resistant disease with few effec...
EGAS00001001876 | EGA
UnknownHyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
Not available
S-EPMC11014662 | biostudies-literature
UnknownMultiomics Profiling of T-cell Leukemia and Lymphoma Enables Targeted Therapeutic Discovery.
Not available
S-EPMC12809113 | biostudies-literature
Genomicsena-DATASET-FIMM-20-06-2016-14:40:19:517-22 - samples
Sequence data is from 4 samples from an adult patient with TCF3-PBX1 t(1;19)-positive acute lymphoblastic leukemia. Exome sequencing was performed on a skin biopsy (normal tissue control) and leukemic bone marrow biopsies taken at diagnosis and at two relapse time points. RNA-sequence data is from ...
EGAD00001002203 | EGA
UnknownCore-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.
Not available
S-EPMC8525333 | biostudies-literature
UnknownIdelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia.
Not available
S-EPMC5220125 | biostudies-literature
GenomicsFIMM DAC
Data Access Committee EGAC00001000429
EGAC00001000429 | EGA
UnknownPerceived sustainability of psychosocial treatment in low- and middle-income countries in South-Eastern Europe.
Not available
S-EPMC9438482 | biostudies-literature
UnknownMetabolic drug survey highlights cancer cell dependencies and vulnerabilities.
Not available
S-EPMC8671470 | biostudies-literature
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