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GenomicsGenome-wide mapping of HATs and HDACs in human CD4+ T cells
Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive genes. We describe here genome-wide mapping of HATs and HDACs ...
ORGANISM(S): Homo sapiens 
2009-08-20 | E-GEOD-15735 | biostudies-arrayexpress
GenomicsChromatin architecture organized by histone variants H3.3 and H2A.Z in the human genome
To understand how chromatin structure is organized by different histone variants, we have measured the genome-wide distribution of nucleosome core particles (NCPs) containing the histone variants H3.3 and H2A.Z in human cells. We find that a special class of NCPs containing both variants is enriched...
ORGANISM(S): Homo sapiens 
2009-07-26 | E-GEOD-13308 | biostudies-arrayexpress
GenomicsChromatin Signatures in Multipotent Human HSCs Indicate the Fate of Bivalent Genes during Differentiation
Histone modifications have been implicated in stem cell maintenance and differentiation. We have analyzed genome-wide changes in gene expression and histone modifications during differentiation of multipotent human primary hematopoietic stem cells/progenitor cells (HSCs/HPCs) into erythrocyte precur...
ORGANISM(S): Homo sapiens 
2009-01-09 | E-GEOD-12646 | biostudies-arrayexpress
TranscriptomicsHistone methylations and gene expression in naïve, central (TCM) and effector (TEM) memory CD8 T cells.
Histone methylations play a major role in regulating the chromatin state and gene expression, yet little is known about their involvement in differential gene expression and function of memory CD8 T cells. Here, we report a genome-wide analysis of two histone H3 methylations (H3K4me3 and H3K27me3) ...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-14422 | biostudies-arrayexpress
GenomicsGenome-wide Analysis of Histone Methylations in Memory CD8+ T Cells
Histone methylations play a major role in regulating the chromatin state and gene expression, yet little is known about their involvement in differential gene expression and function of memory CD8 T cells. Here, we report a genome-wide analysis of two histone H3 methylations (H3K4me3 and H3K27me3) ...
ORGANISM(S): Homo sapiens 
2009-06-12 | E-GEOD-12616 | biostudies-arrayexpress
GenomicsDiscrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during Helper T Cell Differentiation (ChIP-Seq)
Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells; however, their direct roles in driving differentiation are not well understood. Using chromatin immunoprecipitation and massive parallel sequencing, we quantitated the full c...
ORGANISM(S): Mus musculus 
2010-06-18 | E-GEOD-22104 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiles of WT and MLL4-/- after MyoD-induced myogenesis
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50459 | biostudies-arrayexpress
GenomicsGenome-wide maps of MyoD, MLL4 and histone modifications during MyoD-induced myogenesis in WT and MLL4-/- brown preadipocytes
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50465 | biostudies-arrayexpress
GenomicsGenome-wide maps of C/EBPbeta, MLL4 and histone modifications in C/EBPbeta-overexpressed WT and MLL4-/- brown preadipocytes
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50455 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiles of WT and MLL4-/- during brown preadipocyte differentiation
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50172 | biostudies-arrayexpress
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