Sort   by:  
 Page size 
TranscriptomicsChanges in gene expression induced by CDK9 inhibition alone and in combination with fludarabine
Using a transcriptomics approach we explored the mechanism(s) of synergy observed between CDKI-73 and fludarabine in primary CLL cells. The cytotoxic effects of CDKI-73 were associated with transcriptional inhibition of cdk9 target genes including MCL1 and XIAP. In contrast, fludarabine induced the ...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-48258 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD38+ and CD38- cells derived from the same CLL patient reveals distinct gene expression signatures despite their monoclonal origin.
CD38 expression is an important prognostic marker in CLL with high levels of CD38 associated with shorter overall survival. In this study, we used gene expression profiling and protein analysis of highly purified cell-sorted CD38+ and CD38- chronic lymphocytic leukemia cells to elucidate a molecular...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-6321 | biostudies-arrayexpress
UnknownCD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.
Not available
S-EPMC4876311 | biostudies-literature
TranscriptomicsTranscriptional profiling of Acute Myeloid Leukaemia (AML) cells following co-culture with anti-CD44. RNA-seq of anti-CD44 treated, paired, attached, detached and cells in monoculture using two AML cell lines, KG1a and OCI-AML3
Although 80% of AML patients can initially achieve a complete remission, the long-term disease-free survival is only 40% at 6 years with a 10% 5-year survival rate from first relapse. Most patients do not achieve a second remission. Therefore, relapse after initial response to chemotherapy remains a...
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-14052 | biostudies-arrayexpress
UnknownGenetic Variants Associated with Suspected Neonatal Hypoxic Ischaemic Encephalopathy: A Study in a South African Context.
Not available
S-EPMC11900005 | biostudies-literature
TranscriptomicsThe enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting
The ecto-enzyme CD38 is a marker of unfavorable prognosis for chronic lymphocytic leukemia (CLL) patients and an indicator of activation and proliferation of leukemic cells. Here we show that CD38 is enzymatically active in primary CLL cells and that its forced expression increases disease aggressiv...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-56369 | biostudies-arrayexpress
UnknownUNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings.
Not available
S-EPMC11315107 | biostudies-literature
Sort   by:  
 Page size