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ProteomicsLocking CBL in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukaemia (part 1)
Casitas B-lineage lymphoma (CBL) is critical to the negative regulation of receptor protein tyrosine kinases (RTKs). Mutant CBL can act as an adaptor and gain function to cause myeloproliferative diseases. Currently, there is no beneficial treatment available for leukaemia patients with CBL mutation...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051178 | Pride
Peptide inhibitor cblock Cbl’s tyrosine kinase binding domain Leukaemia Casitas b-lineage lymphoma (cbl) 
ProteomicsLocking CBL in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukaemia (part2)
Casitas B-lineage lymphoma (CBL) is critical to the negative regulation of receptor protein tyrosine kinases (RTKs). Mutant CBL can act as an adaptor and gain function to cause myeloproliferative diseases. Currently, there is no beneficial treatment available for leukaemia patients with CBL mutation...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051179 | Pride
Peptide inhibitor cblock Leukaemia Cbl tyrosine kinase binding domain Casitas b-lineage lymphoma (cbl) 
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