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ProteomicsImmunosignatures can predict vaccine efficacy
Mice were immunized with either formalin fixed Influenza A/PR/8/34 (Killed PR8), the 2006-2007 seasonal influenza vaccine, the 2007-2008 seasonal influenza vaccine, a sublethal infection (live PR8) or mock immunized (PBS). Array data was used to distinguish the immunogens from each other and predic...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-51623 | biostudies-arrayexpress
TranscriptomicsInfluenza peptide reactivity within a cohort of age-stratified individuals pre and post vaccination with the 2008/2009 trivalent influenza vaccine
The aim of the study was to test the hypothesis that peptide array reactivity will reveal patterns that can be associated with poor or effective neutralization response to seasonal influenza vaccine We diluted patient sera 1:80 and incubated dilutions on a streptavidin-coated glass surface that was ...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-43446 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocytes from volunteers in a malaria vaccine trial
Volunteers were assessed at study entry, the day of the third vaccination and 24, 72 hours, two weeks after vaccination, and 5 days after challenge. 13/39 vaccinees were protected and 26/39 were not protected. Eleven vaccinees exhibited delayed onset of parasitemia. All infectivity controls develope...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-18323 | biostudies-arrayexpress
ClinicalPersonalized neoantigen peptide vaccine for advanced solid cancer
Interventions: Personalized neoantigen peptide vaccine consists of 15-30 long peptides combined into four distinct immunizing peptide pools with 0.3 mg of each peptide admixed with 0.5 mg poly-ICLC per pool in a volume of 1 ml.;Experimental Biological/Vaccine;Personalized Neoantigen Peptide vaccine ...
2568253 | ecrin-mdr-crc
TranscriptomicsRNA-seq of PBMCs to investigate peptide vaccine immunotherapy biomarkers and response patterns in pediatric gliomas
Low-grade gliomas (LGGs) are the most common brain tumor of childhood. Children with LGGs are ideal candidates for immunotherapy due to slow tumor growth, and as these children are otherwise healthy, and often have intact immune systems. We recently reported in an early phase clinical trial that vac...
ORGANISM(S): Homo sapiens 
2018-04-03 | E-MTAB-6270 | biostudies-arrayexpress
GenomicsArg2-derived peptide vaccine-induced changes in gene expression in Pan02 tumors
Arg2-derived peptide vaccine-induced changes in gene expression in Pan02 tumors
PRJNA875646 | ENA
TranscriptomicsGene expression profiling after vaccination with the RTS,S candidate malaria vaccine in a controlled human malaria infection study
RTS,S is the sole candidate vaccine shown to provide protection against infection to malaria-naive adults challenged with mosquito-borne homologous falciparum malaria and protection against infection and clinical and severe disease to volunteers in malaria-endemic Africa who were exposed to diverse ...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-4629 | biostudies-arrayexpress
GenomicsMutant KRAS-Targeted Long Peptide Vaccine for Patients at High Risk of Developing Pancreatic Cancer
Mutant KRAS-Targeted Long Peptide Vaccine for Patients at High Risk of Developing Pancreatic Cancer
PRJNA1451254 | ENA
GenomicsMutant KRAS-Targeted Long Peptide Vaccine for Patients at High Risk of Developing Pancreatic Cancer
Mutant KRAS-Targeted Long Peptide Vaccine for Patients at High Risk of Developing Pancreatic Cancer
PRJNA1451253 | ENA
TranscriptomicsPre-existing cross-reactive antibody responses do not significantly impact inactivated COVID-19 vaccine-induced neutralization
Recent exposure to seasonal coronaviruses (sCoVs) may stimulate cross-reactive antibody responses against SARS-CoV-2. Previous studies have shown divergent results regarding protective or damaging immunity induced by prior exposure to sCoVs. It is still unknown whether pre-existing humoral immunity ...
ORGANISM(S): Homo sapiens 
2021-10-13 | E-MTAB-11084 | biostudies-arrayexpress
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