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Molecular profiling of brainstem peptidergic neurons
Translational reprogramming of dentate gyrus peptidergic circuitry gates antidepressant efficacy
A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells 
Human cellular models of disease developed using induced pluripotent stem cells (iPSC) have enabled wide-ranging research from investigation of human disease mechanisms to phenotypic drug screens. Pain disorders such as neuropathic pain and headache remain areas of considerable unmet need and are co...
ORGANISM(S): Homo sapiens 
2026-07-20 | GSE331403 | GEO
elective serotonin reuptake inhibitors (SSRIs) exhibit delayed therapeutic effects despite rapid serotonin elevation, suggesting their dependence on slow neuroplastic adaptations. Here, we demonstrate that antidepressant actions require cell type-specific translational regulation of the peptidergic ...
ORGANISM(S): Mus musculus 
2026-05-27 | GSE309750 | GEO
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