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MetabolomicsGlutathione is a host-derived cysteine source for Clostridioides difficile
Clostridioides difficile is the leading cause of nosocomial diarrhea, afflicting approximately half a million people each year in the USA, burdening both individuals’ quality of life and the healthcare system. In the gastrointestinal (GI) tract, C. difficile must acquire essential nutrients to colon...
2026-06-10 | MTBLS14740 | MetaboLights
MetabolomicsProfiling aromatic amino acid metabolome in the human gut microbiota reveals Clostridioides difficile specific N-acyl amino acids

Owing to its compositional and chemical complexity, much of the gut microbiota metabolome remains poorly characterized. Aromatic amino acids (AAAs) have a history of being privileged substrates for the biosynthesis of diverse bioactive metabolites and thus represent a potentially rich source of b...

2026-07-23 | MTBLS13404 | MetaboLights
MetabolomicsClostridioides difficile-commensal interactions are impacted by diet more than differences between strain

The purpose of this study was to investigate how C. difficile metabolism differs between strains as a function of diet. We used three C. difficile strains (R20291, Cd4, and Cd10). Each strain was grown in three different media conditions designed to mimic different diet conditio...

2026-09-18 | MTBLS15045 | MetaboLights
MetabolomicsDietary iron attenuates Clostridioides difficile infection via modulating intestinal immune response and gut microbiota

Clostridioides difficile (C. difficile) causes antibiotic-associated diarrhea. Susceptibility to C. difficile infection (CDI) is largely affected by the gut microbiota, which in turn is influenced by diet. However, the mechanism underlying the interplay between diet and the gut mic...

2024-11-12 | MTBLS11336 | MetaboLights
MetabolomicsParabacteroides distasonis alleviates Clostridioides difficile infection by reshaping bile acid metabolism and the gut microbiota

The aim of this study was to establish a mouse model of Clostridioides difficile infection (CDI) and to investigate the effects of intervention with live Parabacteroides distasonis and its culture supernatant on the fecal bile acid pool using a targeted metabolomics approach. By...

2026-02-04 | MTBLS13831 | MetaboLights
ProteomicsLinking the Vegetative Cell and Spore Proteomes of Peptoclostridium difficile
Peptoclostridium difficile, an anaerobic pathogen, known as causative agent of pseudomembranous colitis and nosocomial diarrhoea. It can also form highly resistant endospores which lay the basic foundations of infection prior germination in the human guts. P. difficile exploits toxins TcdA and TcdB ...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2020-05-26 | PXD012030 | Pride
Proteomics Peptoclostridium difficile Spores One-pot sample processing 
TranscriptomicsBacteroides (Phocaeicola)-driven metabolic remodelling suppresses Clostridioides difficile toxin expression in mixed biofilm communities
The aim of this study was to investigate transcriptomic changes in Clostridioides difficile when cultured as monoculture biofilms or as co-culture biofilms with either Bacteroides (Phocaeicola) dorei or Bacteroides (Phocaeicola) vulgatus. This study was also interested in transcriptomic changes occu...
ORGANISM(S): Phocaeicola vulgatus 
2026-09-23 | E-MTAB-15641 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Clostridioides difficile ∆cwp66 mutant against wild-type control
The experiment intends to reveal the difference in gene expression profiles between the wild-type strain and the ∆cwp66 mutant of Clostridioides difficile. We first constructed the ∆cwp66 mutant, and the phenotypic changes of the ∆cwp66 mutant against the wild-type strain were studied. To further el...
ORGANISM(S): Clostridioides difficile 630 
2022-03-01 | E-MTAB-11180 | biostudies-arrayexpress
TranscriptomicsTemporal RNASeq of C. difficile cultured within synthetic multispecies biofilm relative to C. difficile monoculture biofilms.
This experiment was performed largely to capture the dynamic transcriptional changes occurring in C. difficile when cultured within a 9 species synthetic gut communal consortium over a 48 h time series when cultured as a biofilm in vitro.
ORGANISM(S): Clostridioides difficile 
2026-09-23 | E-MTAB-15646 | biostudies-arrayexpress
GenomicsPlasmids in Peptoclostridium difficile
Investigating the Role of the Large Plasmids found in Peptoclostridium difficile
PRJEB12715 | ENA
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