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TranscriptomicsGenome-wide expression analysis of quiescent versus activated muscle stem cells (satellite cells)
We performed genome-wide gene expression analysis of quiescent/activated muscle stem cells isolated from mouse skeletal muscle by flow cytometry. We analyzed the global changes in gene expression occurring within muscle stem cells (satellite cells) in homeostatic conditions or after cardiotoxin (CTX...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-70376 | biostudies-arrayexpress
TranscriptomicsGeriatric muscle stem cells switch reversible quiescence into senescence (Set 3; Adult vs. Young)
Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging. We report that geriatric satellite cells, compared to old and adult cells, are incapable of maintaining their...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-53726 | biostudies-arrayexpress
TranscriptomicsGeriatric muscle stem cells switch reversible quiescence into senescence (Set 1; Geriatric vs. Young)
Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging. Here we report that geriatric satellite cells, compared to old cells, are incapable of maintaining their norm...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-53724 | biostudies-arrayexpress
TranscriptomicsGeriatric muscle stem cells switch reversible quiescence into senescence (Set 2; Old/Geriatric vs. Young and SAMR1 vs. SAMP8)
Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging and in progeric conditions. Here we report that geriatric satellite cells, compared to old cells, are incapabl...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-53725 | biostudies-arrayexpress
TranscriptomicsGeriatric muscle stem cells switch reversible quiescence into senescence (Set 4; Bmi1-deficient)
Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline in geriatric satellite cells, compared to old cells are incapable of maintaining their normal quiescent state in muscle h...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-53727 | biostudies-arrayexpress
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