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TranscriptomicsThe ISWI ATPase Snf2L is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells
We investigate the role of Snf2l in ovaries by characterizing a mouse bearing an inactivating deletion on the ATPase domain of Snf2l (Ex6DEL). Snf2l mutant mice produce significantly fewer eggs than control mice when superovulated. Thus, gonadotropin stimulation leads to a significant deficit in sec...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-42997 | biostudies-arrayexpress
TranscriptomicsComparative expression profiling identifies differential roles for Myogenin and p38M-NM-1 MAPK signaling in myogenesis
Mitogen activated protein kinase (MAPK) signaling regulates differentiation of many cell types. During myogenesis in particular, p38a MAPK (MAPK14) phosphorylates multiple transcriptional regulators to modulate muscle-specific gene expression. Among the p38a MAPK modulated genes is the muscle-specif...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-25763 | biostudies-arrayexpress
Transcriptomics17β-estradiol accelerates ovarian tumour progression in vivo though the upregulation of GREB1
Exogenous 17β-estradiol (E2) accelerates the progression of ovarian cancer in the transgenic tgCAG-LS-TAg mouse model of the disease. We hypothesized that E2 has direct effects on ovarian cancer cells and this study was designed to determine the molecular mechanisms by which E2 accelerates ovarian t...
ORGANISM(S): Mus musculus 
2014-01-20 | E-GEOD-45271 | biostudies-arrayexpress
TranscriptomicsFibronectin regulates Wnt7a signaling and satellite cell expansion
The influence of the extracellular matrix (ECM) within the stem cell niche remains poorly understood. We found that Syndecan-4 (Sdc4) and Frizzled-7 (Fzd7) form a coreceptor complex in satellite cells and that binding of the ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a t...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-59272 | biostudies-arrayexpress
TranscriptomicsEGFRvIII/STAT3 targets in glioblastoma pathogenesis
Next generation sequencing platforms were used to identify STAT3 targets in the background of EGFRvIII expresssion mRNA of 3 EGFRvIII positive brain tumor stem cell lines (BTSC #68, 73, and 90) were compared to an EGFRvIII negative line (#41) to identify EGFRvIII-regulated targets in human BTSC. EGF...
ORGANISM(S): Mus musculus 
2016-04-13 | E-GEOD-51281 | biostudies-arrayexpress
TranscriptomicsTAL1 knock down in Jurkat cells
We used microarray profiling in Jurkat cells to uncover TAL1 dependent genes in a leukemic context. Clonal Jurkat lines expressing a Doxycycline (Dox) -inducible shRNA against TAL1 coding sequence were generated. A clone in which Dox treatment led to 80% decrease of TAL1 mRNA was chosen.
ORGANISM(S): Homo sapiens 
2010-12-14 | E-GEOD-20544 | biostudies-arrayexpress
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