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TranscriptomicsGenome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for interrogating biology. Engineered proteins based on the CRISPR/Cas9 and TALE systems have been used to alter genomic DNA sequences, control transcription of endogenous genes, and modify epigenetic states. ...
ORGANISM(S): Homo sapiens 
2015-05-27 | E-GEOD-68341 | biostudies-arrayexpress
UnknownCRISPR-SKIP: programmable gene splicing with single base editors.
Not available
S-EPMC6092781 | biostudies-literature
UnknownTreatment of a Mouse Model of ALS by In Vivo Base Editing.
Not available
S-EPMC7132599 | biostudies-literature
UnknownSPLICER: a highly efficient base editing toolbox that enables in vivo therapeutic exon skipping.
Not available
S-EPMC11604662 | biostudies-literature
UnknownCRISPR base editing of cis-regulatory elements enables the perturbation of neurodegeneration-linked genes.
Not available
S-EPMC9734028 | biostudies-literature
GenomicsJ.Costello_20191016_dataset_rnaseq - samples
Description not provided
EGAD00001005435 | EGA
GenomicsInhibiton of the GABPB1L-containing GABP tetramer is sufficient to reverse replicative immortality in TERT promoter mutant glioblastoma cells.
Over 50 types of cancer acquire TERT promoter mutations. These single point mutations reactivate telomerase, allowing for indefinite maintenance of telomere length and enabling cellular immortalization. The transcription factor binding site created by the point mutations specifically recruit the ETS...
EGAS00001002582 | EGA
GenomicsGenome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for interrogating biology. Engineered proteins based on the CRISPR/Cas9 and TALE systems have been used to alter genomic DNA sequences, control transcription of endogenous genes, and modify epigenetic states. ...
ORGANISM(S): Homo sapiens 
2015-04-24 | E-GEOD-57085 | biostudies-arrayexpress
TranscriptomicsRNA-Guided Human Gene Activation by Cas9/CRISPR-Based Engineered Transcription Factors
Synthetic transcription factors can be applied in many areas of biotechnology, medicine, and basic research.  In contrast to current methods based on engineering new DNA-binding proteins, we show that Cas9 fused to a transcriptional activation domain can be targeted by combinations of guide RNA mole...
ORGANISM(S): Homo sapiens 
2013-07-25 | E-GEOD-47114 | biostudies-arrayexpress
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