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TranscriptomicsSingle cell RNAseq of immune and stromal cells in murine lung cancer
Immune responses against tumor cells depend on T lymphocyte attraction and activity within the tumor microenvironment. Specialized immune-interacting fibroblasts, commonly referred to as fibroblastic reticular cells (FRC), form specialized niches in secondary lymphoid organs, originate from embryoni...
ORGANISM(S): Mus musculus 
2024-11-19 | E-MTAB-13708 | biostudies-arrayexpress
TranscriptomicsType I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8+ T cells
Fibroblastic reticular cells (FRC) shape the organization of secondary lymphoid organs and actively promote the induction of immune responses by coordinating the interaction of innate and adaptive immune cells. However, the mechanisms underlying FRC functions during viral infections have remained la...
ORGANISM(S): Mus musculus 
2020-09-01 | E-MTAB-8906 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of immune and stromal cells from the non small cell lung cancer (NSCLC) environment
T lymphocytes can efficiently counteract the growth of tumors within the tumor microenvironment. Specialized immune-interacting fibroblasts, termed fibroblastic reticular cells (FRC) are responsible for the formation of specialized niches promoting immune cell activation in secondary lymphoid organs...
ORGANISM(S): Homo sapiens 
2024-11-19 | E-MTAB-13710 | biostudies-arrayexpress
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