Focusing on host response to infection, we utilized a murine model to develop a blood gene expression signature that accurately classified mice with candidemia and distinguished candidemia from S. aureus bacteremia. Validation of the signature was achieved in an independent cohort of mice. BALB/...
BACKGROUND: Metabolomics has been recognized as a powerful approach for disease screening. In order to highlight potential health issues in subjects, a key factor is the possibility to compare quantitatively the metabolome of their biofluids with reference values from healthy individuals. Such effor...
This model is from the article:
Positive roles for negative regulators in the mating response of yeast.
Houser JR, Ford E, Nagiec MJ, Errede B, Elston TC. Mol Syst Biol
2012 June 5;8:586 22669614
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Abstract:
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Bacterial metabolism in oral biofilms is comprised of complex networks of nutritional chains and biochemical regulations. These processes involve both intraspecies and interspecies networks as well as interactions with components from host saliva, gingival crevicular fluid, and dietary intake. In...
