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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
MetabolomicsThe Metabolic Fate of Oxaliplatin in the Biological Milieu Investigated During In Vivo Lung Perfusion Using a Unique Miniaturized Sampling Approach Based on Solid-Phase Microextraction Coupled with Liquid Chromatography-Mass Spectrometry

Adjuvant chemotherapy after pulmonary metastasectomy for colorectal cancer may reduce recurrence and improve survival rates; however, the benefits of this treatment are limited by the significant side effects that accompany it. The development of a novel in vivo lung perf...

2022-08-02 | MTBLS4982 | MetaboLights
MetabolomicsMetabolic profiling during ex vivo machine perfusion of the human liver (part III)
Not available
ORGANISM(S): Homo sapiens 
ST000413 | MetabolomicsWorkbench
MetabolomicsMetabolic profiling during ex vivo machine perfusion of the human liver (part I)
Not available
ORGANISM(S): Homo sapiens 
ST000412 | MetabolomicsWorkbench
ProteomicsProteomic profiling during normothermic perfusion predicts liver graft quality and outcomes after transplantation
This study investigates the proteomic dynamics of human liver grafts during normothermic machine perfusion (NMP), using mass spectrometry-based analysis. A total of 16 donor livers were perfused with NMP and sampled at three distinct time points to assess molecular changes and their association with...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD067270 | Pride
Quantitative proteomics Graft viability Normothermic machine perfusion Biliary complications Liver transplantation 
TranscriptomicsHuman mesenchymal stromal cell expansion in a 3D scaffold-based system under direct perfusion
Development of systems allowing the maintenance of native properties of mesenchymal stromal cells (MSC) is a critical challenge for studying physiological functions of skeletal progenitors, as well as towards cellular therapy and regenerative medicine applications. Conventional stem cell culture in ...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-52896 | biostudies-arrayexpress
GenomicsGene expression data from Akkermansia perfusion trial
Gene expression data from Akkermansia perfusion trial
PRJNA870572 | ENA
TranscriptomicsTranscription profiling of human samples from intervention study with two doses of iron (as ferrous gluconate via intestinal perfusion) to study the effect on genome wide gene expression in the small intestine
Human intervention study with two doses of iron (as ferrous gluconate via intestinal perfusion) to study the effect on genome-wide gene expression in the small intestine, in order to obtain detailed information about intestinal transcriptomics in vivo.
ORGANISM(S): Homo sapiens 
2006-05-01 | E-MEXP-325 | biostudies-arrayexpress
ProteomicsUrine recirculation prolongs normothermic kidney perfusion for via more optimal metabolic homeostasis – a proteomics study
We describe a proteomics analysis to determine the molecular differences between normothermically perfused (normothermic machine perfusion, NMP) human kidneys with urine recirculation (URC) and urine replacement (UR). Proteins were extracted from 16 kidney biopsies with URC (n=8 donors after brain d...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD021507 | Pride
Proteomics Mass spectrometry Nephrology Kidney transplantation Ischemia reperfusion injury Organ perfusion Iri 
ProteomicsTherapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers
Liver transplantation is the only curative option for end-stage liver disease. Donor shortages necessitate the use of higher risk donor livers, including fatty livers, which are more susceptible to ischemia reperfusion injury. Machine perfusion has improved graft utilization and is typically perform...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD056736 | Pride
Proteomics Transplant Hyperthermia Liver Machine perfusion 
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