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TranscriptomicsIN VITRO SYSTEMS TOXICOLOGY ASSESSMENT OF A PROTOTYPIC MODIFIED RISK TOBACCO PRODUCT SHOWS REDUCED TOXICITY COMPARED TO A CONVENTIONAL CIGARETTE
The toxicity and potential associated molecular mechanism of a reference cigarette, 3R4F and THS2.2 a candidate modified risk tobacco products ((p)MRTP) were investigated with human bronchial epithelial cells using high-throughput screening and whole transcriptomics analysis.
ORGANISM(S): Homo sapiens 
2016-01-05 | E-MTAB-3738 | biostudies-arrayexpress
TranscriptomicsAnatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis.
Objective: In this study, we aimed to evaluate the anti-inflammatory properties of nicotine and anatabine in a dextran sulfate sodium (DSS) mouse model of ulcerative colitis (UC). Methods: C57BL/6 male mice (10 groups with 8 animals each) were orally administered nicotine at a concentration of 5 or ...
ORGANISM(S): Mus musculus 
2020-11-03 | E-MTAB-8543 | biostudies-arrayexpress
TranscriptomicsThe reduction of dextran sulfate sodium-induced colitis severity in mice exposed to cigarette smoke is accompanied by specific gene pathway and microbial shifts.
Background and Aims: The impact of cigarette smoke on inflammatory bowel disease has been established by a large number of epidemiological, clinical, and preclinical studies. Exposure to cigarette smoke is associated with a higher risk of developing Crohn’s disease but is inversely correlated with t...
ORGANISM(S): Mus musculus 
2020-03-03 | E-MTAB-7988 | biostudies-arrayexpress
ProteomicsBlood and urine multi-omics analysis of the impact of e-vaping, smoking and cessation. From exposome to molecular responses
Cigarette smoking is a major cause of preventable morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for smokers who would otherwise continue to smoke. A key...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-26 | MSV000091157 | MassIVE
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