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Microarray Expression Analysis of Circular RNA in Perineural Invasion of Pancreatic Ductal Adenocarcinoma
Construction and validation of a scoring system for perineural invasion-mediated inflammation in gastric cancer
Invasion of cancer cells into peripheral nerves, known as perineural invasion (PNI), is an established risk factor for cancer recurrence and metastasis. However, there are no approaches available to specifically target PNI-competent cancer cells for diagnostic and therapeutic purposes. The lack of i...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD059147 | Pride
This study aimed to investigate the expression profile of circular RNAs (circRNAs) in pancreatic cancer and evaluate their potential as reliable biomarkers and novel diagnostic and therapeutic targets, with a specific focus on molecular characteristics associated with perineural invasion. We employe...
ORGANISM(S): Homo sapiens 
2025-07-30 | GSE303688 | GEO
Gene expression of leaders and laggers MiaPaCa-2 pancreatic cancer cells during perineural invasion
Cancer-Associated Fibroblasts Shape a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer via Histone Lactylation
Perineural invasion (PNI) is considered to be a specific path for the spread of pancreatic cancer cells and PNI is thought to be one of the important factors that determine local recurrence after resection. In addition PNI has been implicated in the pain syndrome that affects the majority of pancrea...
ORGANISM(S): Homo sapiens 
Cancer-Associated Fibroblasts Shape a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer via Histone Lactylation [RNA-seq]
To investigate the mechanisms of cancer cell migration during perineural invasion in pancreatic cancer, we injected fluorescently labelled MiaPaCA-2 cells in the sciatic nerves and collected the leader and lagger cells.
ORGANISM(S): Homo sapiens 
2023-03-31 | GSE207319 | GEO
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