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MetabolomicsAMPK activation orchestrated replicative senescence of periodontal ligament stem cells via regulating metabolomics

BACKGROUND: Periodontal ligament mesenchymal stem cells (PDLSCs) are a promising cell resource for cell-based regenerative medicine in dentistry. PDLSCs inevitably acquire a senescent phenotype after prolonged in vitro expansion, and the key regulators of cells during replicative...

2022-11-15 | MTBLS4568 | MetaboLights
TranscriptomicsComparative gene expression analysis of dental follicle and periodontal ligament in humans
The aim of this study was to evaluate and compare the gene expression profiles of dental follicle and periodontal ligament in humans, which can possibly explain their functions of dental follicle and PDL such as eruption coordination and stress resorption. That may apply this information to clinical...
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-51342 | biostudies-arrayexpress
TranscriptomicsComparative gene expression analysis of the human periodontal ligament in deciduous and permanent teeth
There are histological and functional differences between human deciduous and permanent pediodontal ligament (PDL) tissues. The purpose of this study was to determine the differences between these two types of tissue at the molecular level by comparative gene expression analysis. PDL samples were ob...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-50640 | biostudies-arrayexpress
ProteomicsMouse periodontal ligament tissue after orthodontic tooth movement
Mouse periodontal ligament tissue after orthodontic tooth movement for 14 days. Tissue was dissected by a laser microdissection microscope. Samples were analyzed separately at mesial (compression) and distal (tension) sides.
ORGANISM(S): Mus Musculus (mouse) 
2022-12-16 | PXD030430 | JPOST Repository
TranscriptomicsExpression data from human periodontal ligament
We used microarrays to detect the differences in gene-expression of the periontal ligament between patients with healthy periodontal ligament and patients with periodontitis RNA was extracted directly from the middle third of the human periodontal ligament
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-27993 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed long noncoding RNA expression between periodontal ligament stem cells from healthy periodontal tissue and periodontal ligament stem cells from inflammatory periodontal tissue.
Periodontitis can impair the osteogenic differentiation of human periodontal mesenchymal stem cells, but the underlying molecular mechanisms are still poorly understood. Long noncoding RNAs (lncRNAs) have been demonstrated to play significant roles under both physiologic and pathological conditions....
ORGANISM(S): Homo sapiens 
2016-02-19 | E-GEOD-78074 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chronic inflamed and healthy periodontal ligament cells in vivo
The periodontium are the tissues supporting and investing the tooth and consists of the periodontal ligament, the gingiva, the root cementum, and the alveolar bone. The functions of the cell populations in health and disease regarding the host-mediated tissue destruction are not well understood. To ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7321 | biostudies-arrayexpress
Transcriptomics48-h stretched human periodontal ligament cells
Human periodontal ligament (HPDL) is continuously exposed to mechanical stress in vivo. In this study, in utilizing DNA chips, we analyzed the influences of mechanical stress on the gene expression profile of HPDL cells in vitro. HPDL cells were obtained from extracted first premolars of individuals...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-19118 | biostudies-arrayexpress
TranscriptomicsThe microRNA profile of human periodontal ligament-derived stem cells subjected to dynamic tensile strain
This study aimed to investigate the microRNA expression profile of mechnically strained human periodontal ligament-derived stem cells, and SurePrint G3 Human v16 miRNA Array (Agilent) was employed as a screening platform. We discovered 39 differentially expressed microRNAs between the stretched and ...
ORGANISM(S): Homo sapiens 
2014-09-28 | E-GEOD-41337 | biostudies-arrayexpress
TranscriptomicsExpression of M-CSF from cryopreserved teeth-derived human periodontal ligament cells with different freezing protocols
This study investigated which genes regarding root resorption are upregulated by cryopreservation and whether cryopreservation affects the expression of Macrophage M-bM-^@M-^Scolony stimulating factor. We manufactured the customized template which was made of genes selected regarding root resorption...
ORGANISM(S): Homo sapiens 
2013-01-19 | E-GEOD-43611 | biostudies-arrayexpress
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