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TranscriptomicsTranscription profiling of mouse PERK knockouts vs. wikd type
to study the proliferation of PERK knockout mice islets. The major changes are the proliferation genes Experiment Overall Design: 2days after birth, Experiment Overall Design: Collagenase P digestion Experiment Overall Design: cRNA label with Ambion kit Experiment Overall Design: Hybridization with ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6193 | biostudies-arrayexpress
TranscriptomicsThe eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
Disruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER stress and elicit an unfolded protein response (UPR) that involves translational and transcriptional changes in gene expression aimed at expanding the ER processing capacity and alleviating cellular injury. Three ER ...
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-29929 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse PERK mutant vs. wild type
Molecular characterization of PERK's role in the mouse exocrine pancreas. Postnatal days 16, 19 and 32 were examined. Postnatal day 16 represents a stage immediately prior to severe cytological changes in the exPKO mice. Postnatal day 19 represents the initial stage of severe phenotypes in the ex...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4422 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Perk wild-type and knockout liver perfused without or with 2,5-di-tert-butylhydroquinone
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11684 | biostudies-arrayexpress
TranscriptomicsExpression data from menadione, PERK inhibitor, or control-treated HMLE-shGFP and HMLE-Twist human mammary epithelial cells
Malignant carcinomas that recur following therapy are typically de-differentiated and multi-drug resistant (MDR). De-differentiated cancer cells acquire MDR by upregulating reactive oxygen species (ROS)-scavenging enzymes and drug efflux pumps, but how these genes are upregulated in response to de-d...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-59780 | biostudies-arrayexpress
ProteomicsProteome analysis of BMPR2 mutation PASMCs
Proteome analysis of BMPR2 mutation PASMCs with or without PERK knockout under hypoxia.
ORGANISM(S): Mus Musculus (mouse) 
2021-07-03 | PXD020182 | JPOST Repository
TranscriptomicsTranscription profiling of mouse liver to assess the translational response following activation of GCN2 versus PERK - super series
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11685 | biostudies-arrayexpress
ProteomicsProteomic analysis on human islet with treatment of a PERK inhibitor
Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucida...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD066613 | Pride
Tmt Perk inhibitor Islet 
TranscriptomicsTranscription profiling of Integrated Stress Response induced by tunicamycin or following AP20187 induced dimerization of a Fv2E-PERK chimera in wildtype cells and cells carrying mutations in key ISR signaling molecules.
Comparison of genes induced during activation of the Integrated Stress Response by tunicamycin or following AP20187 induced dimerization of a Fv2E-PERK chimera in wildtype cells and cells carrying mutations in key ISR signaling molecules.
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-700 | biostudies-arrayexpress
ProteomicsDIA-based Proteomic analysis of human islets with treatment of a PERK inhibitor
Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucida...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD074587 | Pride
Human Islets Dia Perk inhibitor 
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