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GenomicsDistinct role of perlecan plays in mesenchymal tissue regeneration through genetic and epigenetic modification
Distinct role of perlecan plays in mesenchymal tissue regeneration through genetic and epigenetic modification
PRJNA1152950 | ENA
TranscriptomicsPerlecan (HSPG2) signalling promotes structural, contractile, and metabolic development during the maturation stage of hPSC-CM differentiation
Perlecan (HSPG2), a multifunctional heparan sulphate proteoglycan (HSPG), is a key player in extracellular matrix maturation and stabilisation. Structurally perlecan is similar to agrin, another HSPG known to contribute to cardiomyocyte phenotype switching by reverting hypertrophy. Although perlecan...
ORGANISM(S): Homo sapiens 
2024-01-23 | GSE229975 | GEO
GenomicsPerlecan (HSPG2) signalling promotes structural, contractile, and metabolic development during the maturation stage of hPSC-CM differentiation
Perlecan (HSPG2) signalling promotes structural, contractile, and metabolic development during the maturation stage of hPSC-CM differentiation
PRJNA956913 | ENA
TranscriptomicsDistinct role of perlecan plays in mesenchymal tissue regeneration through genetic and epigenetic modification
Perlecan is a critical component of basement membrane proteins in tissue development. However, there are few studies investigating direct impact of perlecan on mesenchymal tissue differentiation using genetic modification (gain- and loss-of-function mutations) and epigenetic modification (matrix mic...
ORGANISM(S): Homo sapiens 
2025-03-26 | GSE275764 | GEO
TranscriptomicsAntiangiogenic Antithrombin
Confluent passage-2 HUVECs in Falcon T12.5 flasks grown in the presence or absence of VEGF-165 (10ng/mL) (R&D systems) were treated with human native, cleaved or latent antithrombins (20 5g/mL) for 24 hours in 3 mL M-199 with 2% heat-inactivated FBS and antibiotics. Following this treatment, tot...
ORGANISM(S): Homo sapiens 
2005-12-30 | E-GEOD-3956 | biostudies-arrayexpress
GenomicsStem cell niche organisation in the Drosophila ovary requires the ECM component Perlecan
Stem cell niche organisation in the Drosophila ovary requires the ECM component Perlecan
PRJNA692227 | ENA
UnknownIncreased Risk of Aortic Dissection with Perlecan Deficiency.
Not available
S-EPMC8745340 | biostudies-literature
UnknownPerlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
Not available
S-EPMC2705690 | biostudies-literature
UnknownPerlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients.
Not available
S-EPMC4891130 | biostudies-literature
GenomicsStem cell niche organisation in the Drosophila ovary requires the ECM component Perlecan
Stem cells reside in specialised microenvironments or niches that balance stem cell proliferation and differentiation. The extracellular matrix (ECM) is an essential component of most niches, as it controls niche homeostasis, provides physical support and conveys extracellular signals. Basement memb...
ORGANISM(S): Drosophila melanogaster 
2021-03-31 | GSE164866 | GEO
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