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TranscriptomicsPerlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs
The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here we used extensive global transcriptomic and targeted biochemical analyses to identify novel DIS3L2 substrates in human cells. We show that DIS3L2 regulates pol II transcripts, comprising selected canonical and histon...
ORGANISM(S): Homo sapiens 
2016-07-19 | E-GEOD-82336 | biostudies-arrayexpress
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S-EPMC2959181 | biostudies-literature
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S-EPMC6002834 | biostudies-literature
UnknownThe S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications.
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S-EPMC10363993 | biostudies-literature
UnknownEffective vaccination strategy using SARS-CoV-2 spike cocktail against Omicron and other variants of concern.
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S-EPMC9762654 | biostudies-literature
UnknownIn Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins.
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S-EPMC5285509 | biostudies-literature
UnknownTumor-suppressive effect of S-adenosylmethionine supplementation in a murine model of inflammation-mediated hepatocarcinogenesis is dependent on treatment longevity.
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S-EPMC5739599 | biostudies-literature
UnknownUniversal subunit vaccine protects against multiple SARS-CoV-2 variants and SARS-CoV.
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S-EPMC11272943 | biostudies-literature
UnknownRBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge.
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S-EPMC9045870 | biostudies-literature
UnknownLong non-coding RNA TUG1 is downregulated in Friedreich's ataxia.
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S-EPMC11154142 | biostudies-literature
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