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TranscriptomicsTranscription profiling of human breast cancer cell lines to investigate p53 status in breast cancer
Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor (ER) negative, basal-like and HER2-amplified tumors than in luminal, ER positive tumors. Thus, because p53 mutation statu...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3178 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast carcinoma tissues representing 930 patients with 17.4 years mean follow-up, basal cytokeratin expression was associated with decreased disease-specific survival
Expression profiling studies have classified breast carcinomas into luminal, normal breast-like, HER2 expressing and basal-like groups, with the latter two associated with poor outcomes. This study's objectives were to define an immunohistochemical profile that identifies basal-like tumors, to ident...
ORGANISM(S): Homo sapiens 
2006-09-15 | E-SMDB-2863 | biostudies-arrayexpress
TranscriptomicsRERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer
Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG exp...
ORGANISM(S): Homo sapiens 
2005-07-23 | E-GEOD-2987 | biostudies-arrayexpress
UnknownTumor Suppressor Role for the c-Myb Oncogene in Luminal Breast Cancer
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-21371 | biostudies-other
TranscriptomicsTranscription profiling of human basal-like breast cancer - in vitro and in vivo Analysis of B-Myb
The basal-like breast cancer subtype portends a poor clinical prognosis, and a defining feature of this subtype is the high expression of genes in the “proliferation signature”. B-Myb, a member of the MYB protein family of transcription factors, is highly expressed in the proliferation signatur...
ORGANISM(S): Homo sapiens 
2009-01-18 | E-GEOD-11429 | biostudies-arrayexpress
TranscriptomicsTumor Suppressor Role for the c-Myb Oncogene in Luminal Breast Cancer
The transcription factor c-Myb has been well characterized as an oncogene in several human tumor types, and its expression in the hematopoietic stem/progenitor cell population is essential for proper hematopoiesis. However, the role of c-Myb in mammopoeisis and breast tumorigenesis is poorly unders...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-21371 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mammary tissues from mouse model of breast cancer conditionally expressing Etv6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation
For the largest class of human tumors, those of epithelial origin, little is known about their initiating genetic hits or cells of origin. Whether tissue stem cells or more committed progenitors are targets for transformation is also uncertain. Experience in hematopoietic malignancies and sarcomas ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9343 | biostudies-arrayexpress
TranscriptomicsMPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary tumors with different hormonal requirements
Introduction: Over the past several years, we have been interested in understanding the mechanisms by which hormone-dependent (HD) mammary carcinomas grow in the absence of the stimulatory hormone. We have hypothesized that the stromal compartment plays a pivotal role in the acquisition of the hormo...
ORGANISM(S): Mus musculus 
2011-01-22 | E-GEOD-23214 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary tumors from Brg1 heterozygotes
Mammalian SWI/SNF-related complexes have been implicated in cancer based on some of the subunits physically interacting with RB and other proteins involved in carcinogenesis. Additionally, several subunits are mutated or not expressed in tumor-derived cell lines. Strong evidence for a role in tumori...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-8516 | biostudies-arrayexpress
TranscriptomicsA compact VEGF signature associated with distant metastases and poor outcomes
Results When compared with each other, primary tumors and regional metastases showed statistically indistinguishable gene expression patterns. Supervised analyses comparing patients with distant metastases versus primary tumors or regional metastases showed that the distant metastases were distinct...
ORGANISM(S): Homo sapiens 
2009-03-31 | E-GEOD-3521 | biostudies-arrayexpress
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