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MetabolomicsGlucagon-induced PGC-1aplha4/PPARgamma promotes hepatic lipid storage and macrosteatosis in fasting and MASLD

Please update the study abstract/descriptionThe liver plays a central role in regulating the transition between fasting and feeding states, coordinating glycogen breakdown, gluconeogenesis, fatty acid catabolism, and lipid storage. Disruptions in this balance contribute to metabolic disorders, in...

2026-06-16 | MTBLS13087 | MetaboLights
TranscriptomicsTranscription profiling of mouse liver overexpressing lipin 1beta
Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld mice, a genetic model of lipodystrophy. Lipin 1 appears to be highly involved in the control of fatty acid metabolism. Lipin 1 is most often located in the nucleus, but other studies suggest that lipin also has effects in the cyto...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5538 | biostudies-arrayexpress
UnknownArgan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1α, (PGC-1α), peroxisome proliferator-activated receptor α (PPARα) and estrogen related receptor α (ERRα).
Not available
S-EPMC5889474 | biostudies-literature
UnknownPeroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) is a metabolic regulator of intestinal epithelial cell fate.
Not available
S-EPMC3081029 | biostudies-literature
UnknownEnergy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.
Not available
S-EPMC3265866 | biostudies-literature
UnknownPeroxisome proliferator-activated receptor γ coactivator 1-α overexpression improves angiogenic signalling potential of skeletal muscle-derived extracellular vesicles.
Not available
S-EPMC9949767 | biostudies-literature
UnknownMutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization.
Not available
S-EPMC4293280 | biostudies-literature
TranscriptomicsTranscription profiling of mouse heart from cardiac-specific conditional knockout deletion of menage-a-trios-1 (MAT1)
The Cdk7/cyclin H/menage-a-trois 1 (MAT1) heterotrimer has proposed functions in transcription as the kinase component of basal transcription factor TFIIH and is activated in adult hearts by hypertrophic pathways. Using cardiac-specific Cre, we ablated MAT1 in myocardium. Despite reduced Cdk7 activi...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-6662 | biostudies-arrayexpress
UnknownPeroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes.
Not available
S-EPMC4946932 | biostudies-literature
UnknownDual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction.
Not available
S-EPMC6777908 | biostudies-literature
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