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ProteomicsComprehensive Profiling of early Neoplastic Gastric Microen-vironment Modifications and Biodynamics in Impaired BMP-Signaling Foxl1+-Telocytes
FoxL1+telocytes (TCFoxL1+) are novel gastrointestinal subepithelial cells that form communication axis between the mesenchyme and epithelium. TCFoxL1+ are strategically positioned to be key contributors to the microenvironment through production and secretion of growth factors and extracellular matr...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD038603 | Pride
Bmp signaling  extracellular matrix  me-chanical microenvironment  matrisome Foxl1+-telocytes  epithelial-mesenchymal interaction 
ProteomicsFOXL1+ TELOCYTES IN MOUSE COLON ORCHESTRATE ECM BIODYNAMICS AND WOUND REPAIR RESOLUTION
Recent studies identified FoxL1+-Telocytes (TCFoxL1+) as key players in gut epithelial-mesenchymal interactions impacting the microenvironment. Disruption of BMP-signaling in TCFoxL1+ alters the physical and cellular microenvironment leading to gut pathophysiology, suggesting a role for TCFoxL1+ in ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-11 | PXD036294 | Pride
Bmp signaling  extracellular matrix  mechanical microenvironment  matrisome Foxl1+-telocytes  epithelial-mesenchymal communication 
TranscriptomicsLoss of Hepatocyte-Nuclear-Factor-1α Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation
Although hepatocyte-nuclear-factor-1α (Hnf1α) is crucial for pancreas and liver functions, it is believed to play a limited functional role for intestinal epithelial functions. The aim of this study was to assess the consequences of abrogating Hnf1α on the maintenance of adult small intestinal epit...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-23040 | biostudies-arrayexpress
TranscriptomicsHepatocyte-nuclear-factor-4a promotes gut neoplasia in mice and protects against the production of reactive oxygen species
Hepatocyte-nuclear-factor-4? (??Hnf4?) is a transcription factor that controls epithelial cell polarity and maturation during embryogenesis. Hnf4? conditional deletion during post-natal development results in minor consequences on intestinal epithelium integrity but promotes activation of the Wnt/...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-20968 | biostudies-arrayexpress
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