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MetabolomicsMetabolic plasticity of lipid storage and utilization governs fungal persister formation within macrophages
The ability of Candida glabrata to survive within macrophages creates a reservoir for recurrent infections and antifungal failure, yet the underlying mechanisms remain elusive. Here, using a host-mimicking in vitro evolution model, we identify asparagine synthetase (ASN2) as a critical genetic deter...
2026-04-22 | MTBLS14351 | MetaboLights
TranscriptomicsE. coli BW25113 K-12 hfq vs. wild-type persister
Persisters are cells which evade stresses like antibiotics and which are characterized by reduced metabolism and a lack of genetic alterations required to achieve this state. We showed previously that MqsR and MqsA of Escherichia coli are a toxin-antitoxin pair that influence cell physiology (e.g.,...
ORGANISM(S): Escherichia coli 
2009-11-07 | E-GEOD-18852 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of drug-tolerant persister BT474 breast cancer cells derived from lapatinib treatment
Acquired drug resistance prevents targeted cancer therapy from achieving stable and complete responses. Emerging evidence implicates a key role for nonmutational mechanisms including changes in cell state during early stages of acquired drug resistance. Targeting nonmutational resistance may therefo...
ORGANISM(S): Homo sapiens 
2016-07-28 | E-GEOD-84896 | biostudies-arrayexpress
TranscriptomicsExpression data from persister and normal cells of Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa PAO1 persister and normal cells were treated with and without Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) to understand the effect of GM-CSF on gene expression of PAO1. We used DNA microarrays to identify the down-regulated and up-regulated genes after GM-CSF tre...
ORGANISM(S): Pseudomonas aeruginosa 
2014-11-25 | E-GEOD-63588 | biostudies-arrayexpress
TranscriptomicsEffects of (E)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8) on E. coli RP437 persister cells (two biological replicates)
Eighteen genes in RP437 persister cells were consistently induced/decreased by treatment with 5 µg/mL BF8 for 1 h. Persister cells were isolated from RP437 overnight cultures and treated with and without BF8 for microarray analysis.
ORGANISM(S): Escherichia coli 
2013-02-13 | E-GEOD-44273 | biostudies-arrayexpress
TranscriptomicsEffects of (E)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one (BF8) on P. aeruginosa PAO1 persister cells (three biological replicates)
Twenty eight genes in PAO1 persister cells were consistently induced by treatment with 1 ug/mL BF8 for 1 h. Persister cells were isolated from PAO1 overnight cultures and treated with and without BF8 for microarray analysis.
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2012-03-24 | E-GEOD-36753 | biostudies-arrayexpress
GenomicsFSP1 and histone deacetylases suppress cancer persister cell ferroptosis
FSP1 and histone deacetylases suppress cancer persister cell ferroptosis
PRJNA1295369 | ENA
GenomicsGenome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL) [ChIP-seq]
Here we modeled T-ALL resistance to Notch inhibition, identifying M-bM-^@M-^XpersisterM-bM-^@M-^Y cells that readily expand in the presence of gamma secretase inhibitor (GSI) and the absence of Notch signaling. Rare persister cells are already present in naM-CM-/ve T-ALL populations, and the reversi...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54379 | biostudies-arrayexpress
GenomicsscRNAseq of PC9 parental and persister cells
scRNAseq of PC9 parental and persister cells
PRJNA783931 | ENA
Genomicsm6A-seq of melanoma parental and persister cells
m6A-seq of melanoma parental and persister cells
PRJNA566396 | ENA
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