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MetabolomicsMetabolic plasticity of lipid storage and utilization governs fungal persister formation within macrophages
The ability of Candida glabrata to survive within macrophages creates a reservoir for recurrent infections and antifungal failure, yet the underlying mechanisms remain elusive. Here, using a host-mimicking in vitro evolution model, we identify asparagine synthetase (ASN2) as a critical genetic deter...
2026-04-22 | MTBLS14351 | MetaboLights
TranscriptomicsE. coli BW25113 K-12 hfq vs. wild-type persister
Persisters are cells which evade stresses like antibiotics and which are characterized by reduced metabolism and a lack of genetic alterations required to achieve this state. We showed previously that MqsR and MqsA of Escherichia coli are a toxin-antitoxin pair that influence cell physiology (e.g.,...
ORGANISM(S): Escherichia coli 
2009-11-07 | E-GEOD-18852 | biostudies-arrayexpress
GenomicsGenome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL) [ChIP-seq]
Here we modeled T-ALL resistance to Notch inhibition, identifying M-bM-^@M-^XpersisterM-bM-^@M-^Y cells that readily expand in the presence of gamma secretase inhibitor (GSI) and the absence of Notch signaling. Rare persister cells are already present in naM-CM-/ve T-ALL populations, and the reversi...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54379 | biostudies-arrayexpress
GenomicsFSP1 and histone deacetylases suppress cancer persister cell ferroptosis
FSP1 and histone deacetylases suppress cancer persister cell ferroptosis
PRJNA1295369 | ENA
TranscriptomicsGene expression profiling of drug-tolerant persister BT474 breast cancer cells derived from lapatinib treatment
Acquired drug resistance prevents targeted cancer therapy from achieving stable and complete responses. Emerging evidence implicates a key role for nonmutational mechanisms including changes in cell state during early stages of acquired drug resistance. Targeting nonmutational resistance may therefo...
ORGANISM(S): Homo sapiens 
2016-07-28 | E-GEOD-84896 | biostudies-arrayexpress
GenomicsAntigenic cancer persister cells survive direct T cell attack
Antigenic cancer persister cells survive direct T cell attack
PRJNA1219558 | ENA
GenomicsDFFB suppresses interferon to enable cancer persister cell regrowth
DFFB suppresses interferon to enable cancer persister cell regrowth
PRJNA802916 | ENA
GenomicsIdentification and genetic dissection of convergent persister cell states
Identification and genetic dissection of convergent persister cell states
PRJNA954422 | ENA
TranscriptomicsExpression data from persister and normal cells of Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa PAO1 persister and normal cells were treated with and without Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) to understand the effect of GM-CSF on gene expression of PAO1. We used DNA microarrays to identify the down-regulated and up-regulated genes after GM-CSF tre...
ORGANISM(S): Pseudomonas aeruginosa 
2014-11-25 | E-GEOD-63588 | biostudies-arrayexpress
UnknownDNA fragmentation factor B suppresses interferon to enable cancer persister cell regrowth.
Not available
S-EPMC12717002 | biostudies-literature
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