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TranscriptomicsResponse to a LNA miR-92a inhibitor in immortalized human bronchial epithelial cells.
Lung cancer is the leading cause of cancer-related fatalities. Recent success developing genotypically-targeted therapies, with potency only in well-defined subpopulations of tumors, suggests a path to improving patient survival. We utilized a library of oligonucleotide inhibitors to microRNAs, a cl...
ORGANISM(S): Homo sapiens 
2014-12-10 | E-GEOD-64007 | biostudies-arrayexpress
UnknownResponse to a LNA miR-92a inhibitor in immortalized human bronchial epithelial cells
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-64007 | biostudies-other
TranscriptomicsTranscription profiling of mouse 344SQ lung adenocarcinoma cells with high metastatic potential (syngeneic mouse model)
The biologic basis for NSCLC metastasis is not well understood. Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. As a tool to investigate...
ORGANISM(S): Mus musculus 
2009-11-28 | E-GEOD-14458 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 344SQ lung adenocarcinoma cells under forced miR-200 expression
Metastatic disease is a primary cause of cancer-related death, and factors governing tumor cell metastasis have not been fully elucidated. Here we addressed this question by using tumor cell lines derived from mice that develop metastatic lung adenocarcinoma owing to expression of mutant K-ras and p...
ORGANISM(S): Mus musculus 
2009-11-28 | E-GEOD-15741 | biostudies-arrayexpress
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