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TranscriptomicsRibosome profiling with translation inhibitors reveals pervasive translation in murine ES cells
Ribosome profiling with translation inhibitors reveals pervasive translation in murine ES cells. Ribosome profiling or stranded RNAseq (ribominus) with murine embryonic stem cells treated with either DMD-pateamineA, Puromycin, Harringtonine or vehicle (no drug control). Two replicates per condition.
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-67741 | biostudies-arrayexpress
ProteomicsDiversity in pervasive translation. A new translational landscape of yeast.
Pervasive translation is a widespread phenomenon that plays an important role in de novo gene birth; however, its underlying mechanisms remain unclear. Based on multiple Ribosome Profiling datasets, we investigated the translational landscape of coding and noncoding regions of yeast. Therefore, we d...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-09-04 | PXD040766 | Pride
Genome evolution Mass spectrometry Non-canonical translation signals De novo coding products Noncoding genome Pervasive translation 
GenomicsPervasive Translation in Mycobacterium tuberculosis
Pervasive Translation in Mycobacterium tuberculosis
PRJEB46152 | ENA
GenomicsPervasive, non-functional translation in mycobacterium tuberculosis
Pervasive, non-functional translation in mycobacterium tuberculosis
PRJEB32965 | ENA
TranscriptomicsRibosome Profiling Reveals Pervasive Translation Outside of Annotated Protein-Coding Genes
Ribosome profiling suggests that ribosomes occupy many regions of the transcriptome thought to be non-coding, including 5' UTRs and lncRNAs. Apparent ribosome footprints outside of protein-coding regions raise the possibility of artifacts unrelated to translation, particularly when they occupy multi...
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-60095 | biostudies-arrayexpress
TranscriptomicsRibosome profiling data obtained from HEK293T cells 30 minutes after treatment with arsenite to a final concentration of 40 M-BM-5M
Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eIF2. However, the persistent translation of certain mRNAs is required for deployment of an adequate s...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-55195 | biostudies-arrayexpress
TranscriptomicsRibosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster
Ribosomes can read through stop codons in a regulated manner, elongating rather than terminating the nascent peptide. Stop codon readthrough is essential to diverse viruses, and phylogenetically predicted to occur in a few hundred genes in Drosophila melanogaster, but the importance of regulated rea...
ORGANISM(S): Drosophila melanogaster 
2013-12-05 | E-GEOD-49197 | biostudies-arrayexpress
GenomicsPervasive functional translation of noncanonical open reading frames
Pervasive functional translation of noncanonical open reading frames
PRJNA544411 | ENA
TranscriptomicsPervasive Translation in Mycobacterium tuberculosis
The vast majority of bacterial open reading frames (ORFs) are identified by automated prediction algorithms. However, these algorithms fail to identify ORFs that deviate from the canonical features of ORFs such as a length of >50 codons, and the presence of an upstream Shine-Dalgarno sequence. Here,...
ORGANISM(S): Mycobacterium tuberculosis 
2021-06-30 | E-MTAB-10695 | biostudies-arrayexpress
GenomicsPervasive translation of circular RNAs driven by short IRES-like elements
Pervasive translation of circular RNAs driven by short IRES-like elements
PRJNA639721 | ENA
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