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Gene expression analysis of N-Acetyl L-cysteine induced differentiation of NHEK cells in vitro.
ORGANISM(S): Homo sapiens 
Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism. Yet the contribution of AMP-activated kinase (AMPK), a central energy sensor promoting c...
2024-08-16 | MTBLS10647 | MetaboLights
Neutrophils form the most abundant leukocyte subset and are central to many disease processes. Technical challenges in transcriptomic profiling have prohibited genetical genomic approaches to date. Here, we map expression quantitative trait loci (eQTL) in peripheral blood CD16+ neutrophils from 101 ...
ORGANISM(S): Homo sapiens 
Gene expression arrays and genotyping data in primary human monocytes from healthy individuals of European ancestry that have either been unstimulated (baseline), exposed to Lipopolysaccharide (90 minutes or 6 hours duration), muramyl-dipeptide (90 minutes or 6 hours duration) or transfected with 5’...
ORGANISM(S): Homo sapiens 
The human BTG1 and BTG2 genes are targeted by genetic alterations in hematological malignancies. In this study we examined the unique and overlapping functions of Btg1 and Btg2 in mouse B cell development. Mice deficient for Btg1 and Btg2 displayed the strongest phenotype with a decrease in B cell n...
ORGANISM(S): Mus musculus 
RNAi mediated knockdown of BTG1 in the acute lymphoblastic cell line RS4;11 causes this cell line to become resistant to prednisolone treatment when compared to control cells. In this experiment we treated BTG1 knockdown RS4;11 cells and control RS4;11 cells either with prednisolone or a vehicle con...
ORGANISM(S): Homo sapiens 
Data Access Committee EGAC00001000319
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