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TranscriptomicsA Chromatin Immunoprecipitation Approach Based on BAC Transgenesis
We have devised a technology that enables chromatin immunoprecipitation (ChIP) experiments in cultured human cells by circumventing both the laborious production of protein-specific antibodies and the optimization of crosslinking/immunoprecipitation conditions for each protein. Our approach utilizes...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10845 | biostudies-arrayexpress
MetabolomicsSmall intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an o...
2019-04-30 | MTBLS876 | MetaboLights
Genomicsena-DATASET-WIMM-10-10-2016-16:24:16:111-38 - samples
Whole Genome Sequencing data set for the study "Premalignant SOX2 in ovarian cancer patients"
EGAD00001002734 | EGA
GenomicsPremalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies
To identify early driver mutations in ovarian cancer cells, we used dense whole genome sequencing of micrometastases and microscopic residual disease collected at three time points from a single patient during treatment for high-grade serous ovarian cancer (HGSOC). Laser capture microdissection of t...
EGAS00001001909 | EGA
GenomicsOvarian Cancer Laboratory, University of Oxford
Data Access Committee EGAC00001000518
EGAC00001000518 | EGA
TranscriptomicsSelective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are involved in the recruitment of additional factors that mediate histone modifications and enable transcription. A compound, I-BET-762, that inhibits binding of an acetylated histone peptide to BRD4 and other pro...
ORGANISM(S): Mus musculus 
2012-08-03 | E-GEOD-39886 | biostudies-arrayexpress
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