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TranscriptomicsComparative transcriptome analysis of yeast expressing the fungal desaturases
To study how the presence of PUFAs influences central cellular processes, and in order to perform lipidome, transcriptome and molecular studies we decided to use yeast as a model organism. We therefore co-expressed Δ12-desaturase and Δ6- desaturase genes from Mucor rouxii in S. cerevisiae with the o...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-27 | E-GEOD-20155 | biostudies-arrayexpress
TranscriptomicsChronological Aging of Yeast in SD medium
Yeast grown in synthetic complete medium (SD) until glucose depletion is aged chronologically. Cells are stressed by lacking of nutrients and accumulating toxic substances, and thus undergo gene expression changes in response to those. We performed microarray experiments to capture gene expression p...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-04 | E-GEOD-55508 | biostudies-arrayexpress
TranscriptomicsBalancing Protein Folding and Disulfide Bond Formation Rates is Key to Mitigating Secretory Stress
The protein secretory pathway must maintain homoeostasis while producing a wide assortment of proteins in different conditions. It is also used extensively to produce many useful proteins in biotechnology. As such, secretory pathway dysfunction can be highly detrimental to the cell, resulting in ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-12-01 | E-GEOD-27062 | biostudies-arrayexpress
ModelsYeast Apoptosis
Programmed cell death (PCD) is an essential cellular mechanism that is evolutionary conserved, mediated through various pathways and acts by integrating different stimuli. Many diseases such as neurodegenerative diseases and cancers are found to be caused by, or associated with, regulations in the c...
2135 | Cell Collective
ModelsHerrgård2008_MetabolicNetwork_Yeast
This is a reconstruction of the biochemical network of the yeast Saccharomyces cerevisiae carried out at a jamboree organized in April 2007 in the Manchester Centre for Integrative Systems Biology. It is the result of a consensus merger of two previous reconstr...
2005-01-01 | MODEL0072364382 | BioModels
TranscriptomicsExperimental systems biology: Lessons from an integrated, multi-laboratory study in yeast
We undertook an inter-laboratory effort to generate high-quality quantitative data for a very large number of cellular components in yeast using transcriptome and metabolome analysis. We ensured the high-quality of the experimental data by evaluating a wide range of sampling and measurement techniqu...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-01 | E-GEOD-24234 | biostudies-arrayexpress
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