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TranscriptomicsSpatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation
Interaction of hematopoietic progenitors with the thymic stromal microenvironment induces them to proliferate, adopt the T cell fate, and asymmetrically diverge into multiple T lineages. Progenitors at various developmental stages are stratified among different regions of the thymus, implying that t...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-18281 | biostudies-arrayexpress
TranscriptomicsIdentification of E47 targets
In maturing T-lineage cells, the helix-loop-helix protein E47 has been shown to enforce a critical proliferation and developmental checkpoint commonly referred to as β selection. To examine how E47 regulates cellular expansion and developmental progression, we have used an E2A deficient lymphoma c...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-4784 | biostudies-arrayexpress
TranscriptomicsHarnessing of the Nucleosome Remodeling Deacetylase complex controls lymphocyte development and prevents leukemogenesis
Cell fate decisions depend on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2u Nucleosome Remodeling and Deacetylase (NuRD) complex is controlled by the Ikaros family of lymphoid-lineage determining proteins. Ikaros, an integral component ...
ORGANISM(S): Mus musculus 
2011-11-13 | E-GEOD-32311 | biostudies-arrayexpress
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