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GenomicsSequencing-based ssDNA detection
Meiotic DNA double stranded breaks (DSBs) initiate genetic recombination in discrete areas of the genome called recombination hotspots. Although DSBs can be directly mapped using ChIP-Seq and antibody against ssDNA-associated proteins, genome-wide mapping of recombination hotspots in mammals is stil...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-34592 | biostudies-arrayexpress
GenomicsSupression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic spo11 allele
Homologous recombination is the key process that generates genetic diversity and drives evolution. SPO11 protein triggers recombination by introducing DNA double stranded breaks at discreet areas of the genome called recombination hotspots. The hotspot locations are largely determined by the DNA bin...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-48493 | biostudies-arrayexpress
TranscriptomicsRecombination initiation maps of individual human genomes
DNA double-strand breaks (DSBs) are introduced in meiosis to initiate recombination and to generate crossovers, the reciprocal exchanges of genetic material between parental chromosomes. Here we present the first high-resolution map of meiotic DSBs in individual human genomes. Comparing DSB maps bet...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-59836 | biostudies-arrayexpress
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